Immunohistochemical characterization of leucocyte subpopulations in endometriotic lesions

D J Oosterlynck, F J Cornillie, Freddy Cornillie, Mark Waer, M Waer, Philippe R. Koninckx, P R Koninckx
Archives of gynecology and obstetrics · 1993 · vol. 253(4) , pp. 197–206 · doi:10.1007/bf02766646 · PMID:8161254 · W2005527784
article OA: closed CC0 ⤵ 42 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This study characterized leucocyte subpopulations in endometriotic lesions, finding T lymphocytes and macrophages to be most frequent, with few B cells and no natural killer cells of certain types.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This study immunohistochemically characterized leukocyte subpopulations in endometriotic lesions from 15 biopsies excised by CO2 laser, using an avidin-biotin immunoperoxidase technique and a panel of monoclonal antibodies for multiple immune cell markers. Common antigen (anti-Hle-1) positive cells were found in all lesions and were the most frequent stromal leukocytes, with T lymphocytes being the most frequent subpopulation alongside macrophages, and a CD4/CD8 ratio of 0.78. Anti-leu-7 and/or anti-leu-11 positive cells were not detected, while anti-leu-19 positive cells and macrophages were present, and very few B cells were observed; the authors explicitly note that the possible importance of these intra-endometriotic leukocytes for endometriosis pathophysiology will be discussed. This paper is centrally about endometriosis — it specifically maps and quantifies leukocyte subpopulations within endometriotic lesions by immunohistochemistry.

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Condition tags

mesh:D004715

MeSH descriptors

B-Lymphocyte Subsets Endometriosis T-Lymphocyte Subsets Uterine Diseases Antibodies, Monoclonal Avidin Biopsy Biotin B-Lymphocyte Subsets B-Lymphocyte Subsets CD4-CD8 Ratio Endometriosis Evaluation Studies as Topic Female Humans Immunoenzyme Techniques Laparoscopy Severity of Illness Index T-Lymphocyte Subsets T-Lymphocyte Subsets

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