The role of the B lymphocytes in endometriosis: A systematic review

Luiza Gama Coelho Riccio, L G C Riccio, Baracat EC, E C Baracat, Edmund Chada Baracat, Charles Chapron, C. Chapron, Chapron C, Frédéric Batteux, Batteux F, F. Batteux, M S Abrão, Maurício Simões Abrão, Abrão MS
Journal of Reproductive Immunology · 2017 · vol. 123 , pp. 29–34 · doi:10.1016/j.jri.2017.09.001 · PMID:28910679 · W2752080567
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This systematic review explores the involvement of B lymphocytes in the pathogenesis and progression of endometriosis.

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Abstract

The physiopathology of endometriosis is not completely understood and its progression is associated with a local and systemic inflammatory reaction. It is important to clarify the potential role of the immune system to better understand its implication in the pathogenesis of endometriosis, which includes the study of the role of B cells and antibodies. The aim of this study was to review the literature about the role of B lymphocytes in endometriosis. A search for "endometriosis", "B cells" and "B lymphocytes" in databases resulted in 140 citations; after applying inclusion and exclusion criteria, a total of 22 studies were assessed. The analyzed samples in the studies varied and different markers and techniques were used by the authors to evaluate the direct or indirect role of B lymphocytes in endometriosis. Most studies demonstrated increased number and/or activation of B cells while seven studies found no difference and two studies showed decreased number of B cells. Increased B lymphocytes and excessive production of autoantibodies in endometriosis have been described in the literature, but their role in the development of the disease is not well understood. Moreover, the association of these factors with clinical symptoms, location and severity of the disease has not been investigated. Further studies are necessary to clarify the role of B cells in the development of endometriosis and propose new therapeutic strategies such as the use of drugs that target these cells.

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Condition tags

endometriosis

MeSH descriptors

B-Lymphocytes B-Lymphocyte Subsets Endometriosis Animals Autoantibodies Autoantibodies Biomarkers Biomarkers B-Lymphocytes B-Lymphocyte Subsets Endometriosis Endometrium Endometrium Female Humans Inflammation Mediators Inflammation Mediators

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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