Evaluation of HLA-DQ2 and HLA-DQ8 haplotypes in patients with endometriosis, A case-control study

Marina P Andres, Marina Paula Andres, Alessandra Peloggia, Henrique M Abrao, Henrique Mendonca Abrão, Thais F Magalhaes, Thaís Fontes de Magalhães, João Siufi Neto, Mauricio Simões Abrão, Maurício Simões Abrão
Clinics (Sao Paulo, Brazil) · 2024 · vol. 79 , pp. 100317 · doi:10.1016/j.clinsp.2023.100317 · PMID:38432123 · W4392400779
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Abstract

OBJECTIVE: To evaluate the relationship between genetic haplotypes associated with celiac disease (Human Leucocyte Antigen [HLA] DQ2 and DQ8) with the diagnosis, clinical presentation, and location of endometriosis in Brazilian women. METHOD: A retrospective cross-sectional study, was conducted in a Tertiary hospital. PATIENTS: Women aged 18-50 years who underwent HLA-DQ2 and HLA-DQ8 haplotype analysis. INTERVENTION: The patients were divided into endometriosis and control groups and evaluated for symptoms; endometriosis location, American Society for Reproductive Medicine (ASRM) stage, and the presence of anti-tissue transglutaminase IgA (anti-TgA), HLA-DQ2, and HLA-DQ8 markers. RESULTS: A total of 434 consecutive patients with (n = 315) and without (n = 119) endometriosis were included. Pain and infertility were more frequent in the endometriosis group than in the control group. The presence of HLA-DQ2, HLA-DQ8, and anti-TgA was similar between both groups. The presence of HLA-DQ2 and HLA-DQ8 markers did not differ based on age, pain symptoms, ASRM stage, or endometriosis location. CONCLUSION: Although there are similarities in inflammatory markers and pathophysiology between celiac disease and endometriosis, this study found no significant associations in the presence of HLA-DQ2 or HLA-DQ8 haplotypes and endometriosis.

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Outcome instruments

VAS-pain

Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Celiac Disease Celiac Disease Celiac Disease Celiac Disease Celiac Disease Celiac Disease Celiac Disease Celiac Disease Celiac Disease Celiac Disease Celiac Disease Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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