Clinics (Sao Paulo, Brazil)

INTRODUCTION: Preimplantation Genetic Testing (PGT-A) has been increasingly used in IVF to improve embryo selection. However, its clinical utility in patients with a good prognosis remains debated. There is a lack of robust scientific evide…

OBJECTIVE: The research focuses on understanding how GSDMD and Caspase-1, key regulators of pyroptosis, influence postoperative recurrence in Endometrial Polyps (EPs) and examines whether a combined biomarker can effectively predict recurre…

OBJECTIVE: Chronic Pelvic Pain (CPP) presents significant diagnostic challenges, often involving multiple pathologies, including endometriosis and pelvic venous disorders. This study examined the prevalence of endometriosis among women with…

PURPOSE: To evaluate the prevalence of Irritable Bowel Syndrome (IBS) and its related sociodemographic, nociceptive, neuropathic, nociplastic, psychosocial, and systemic factors in patients with Chronic Pelvic Pain (CPP). MATERIALS AND MET…

BACKGROUND: Ovarian cancer is a leading cause of mortality among women globally. This study aimed to evaluate the diagnostic value of CA-125, HE4, and the ROMA index in identifying ovarian cancer in patients in Bangladesh. METHODS: This ca…

BACKGROUND: Endometriosis diagnosis is challenging due to non-specific symptoms that overlap with other gynaecological conditions. This study proposes a non-invasive Machine Learning (ML) ‒ based urine test using Attenuated Total Reflection…

OBJECTIVE: To provide a protocol for the diagnosis and management of Acute Abnormal Uterine Bleeding (AUB) during menacme, addressing common causes, clinical evaluation, and treatment options. METHODS: A review of current evidence and guid…

OBJECTIVE: To investigate the incidence of postoperative venous thromboembolism in women with uterine adenomyosis treated using different surgical methods, and to evaluate the associated clinical and laboratory parameters, including thrombo…

OBJECTIVE: This study aimed to evaluate the effect of Omega-3 Fatty Acids (ω-3 PUFAs) on endometriosis. DESIGN: The authors conducted a comprehensive search of the PubMed, Embase, Cochrane Library and Web of Science databases, focusing exc…

Background This study aimed to investigate the effects of LDE-MTX on acute cerebral infarction. The study focuses on how LDE-MTX can influence the outcomes of ischemic stroke in a rat model, specifically examining its neuroprotective proper…

BACKGROUND: To investigate the combined effect of transperineal ultrasound and Shear Wave Elastography (SWE) in the evaluation and monitoring of pelvic floor functions after total hysterectomy. METHODS: Fifty-two women who planned to under…

BACKGROUND: The relationship between negative emotions and chronic respiratory diseases remains largely unexplored. In this study, we employ Mendelian Randomization (MR) to investigate the potential causal relationship between negative emot…

The incorporation of long-acting reversible contraceptives (LARCs) into reproductive health strategies is crucial for enhancing access to effective contraception and reducing unplanned pregnancies (UPs). Evidence shows that even a modest sh…

OBJECTIVE: To evaluate the relationship between genetic haplotypes associated with celiac disease (Human Leucocyte Antigen [HLA] DQ2 and DQ8) with the diagnosis, clinical presentation, and location of endometriosis in Brazilian women. METH…

AIM: miR-141-5p expression in patients with Early Spontaneous Abortion (ESA) and its correlation with hormone levels during pregnancy were investigated. METHODS: A total of 70 pregnant women with ESA were selected as the research group, an…

Endometriosis's pathophysiology remains incompletely understood, with evidence pointing towards a dysregulated immune response. Regulatory T (Treg) cells, pivotal in maintaining self-tolerance, may facilitate the survival of ectopic endomet…

It is time to change the definition: Endometriosis is no longer a pelvic disease Endometriosis is a chronic, inflammatory, hormone-dependent gynecologic condition characterized by the presence of endometrial-like tissue outside the uterine …

Studies regarding serum Progesterone (P4) concentration and Clinical Pregnancy Rates (CPR) in fresh Embryo Transfer (ET) after Controlled Ovarian Stimulation Cycles (COS) remain inconclusive. To find a P4 cutoff point on fresh ET day associ…

OBJECTIVES: Ad fontes, the status of the thyroid gland, and metabolic disturbance lead to the alteration of oxygenation. In pregnancy, it is particularly crucial to possess all predictive parameters. METHODS: This cross-sectional study was…

BACKGROUND: Endometriosis is a chronic inflammatory disease affecting about 10% of women of reproductive age. Endometrioma is the most common presentation of endometriosis in ovaries. OBJECTIVES: Herein, the authors study the effect of the…

Recent studies have found that lncRNA-MEG3(MEG3) plays an important role in the development of EMs (Endometriosis), but the specific mechanism needs to be further explored. This study aimed to investigate the effect of MEG3 on the prolifera…

• Homeopathy is based on heterodox and complementary four scientific assumptions. • Pseudosceptics deny these assumptions and any scientific evidence that proves them. • The dossier describes hundreds of clinical and experimental studies in…

BACKGROUND: Infertility is caused by heterogeneous risks, but most of them are unexplained. The sperm DNA Fragmentation Index (DFI) was increasingly acknowledged as a parameter for the evaluation of male infertility. This study aimed to inv…