CYP2C19 metabolic estrogen phenotypes and endometriosis risk in Brazilian women

Jamila Alessandra Perini, Daniel Escorsim Machado, Cardoso JV, Jéssica Vilarinho Cardoso, Vanessa Camara Fernandes, Fernandes VC, Claudio José Struchiner, Struchiner CJ, Guilherme Suarez-Kurtz, Suarez-Kurtz G
Clinics (Sao Paulo, Brazil) · 2023 · vol. 78 , pp. 100176 · doi:10.1016/j.clinsp.2023.100176 · PMID:36893562 · PMC10018429
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This study investigated the association between CYP2C19 metabolic estrogen phenotypes and endometriosis risk in Brazilian women.

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This study investigates the association between CYP2C19 metabolic phenotypes and the risk of endometriosis in a cohort of Brazilian women. The researchers analyzed genetic variations in the CYP2C19 enzyme, which plays a role in estrogen metabolism, to determine if specific metabolic profiles correlate with disease prevalence. The findings indicate that certain CYP2C19 genotypes are significantly associated with an increased susceptibility to endometriosis among the studied population. This paper is centrally about endometriosis — specifically examining the genetic basis of estrogen metabolism as a risk factor for the condition.

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The authors thank all staff members of the Hospital Federal dos Servidores do Estado (HFSE) and Hospital Moncorvo Filho (HMF) for collaborating and allowing this study to happen. Financial support was provided by grants from the Brazilian agencies: Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

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Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.clinsp.2023.100176 .

Declaration

The authors declare no conflicts of interest.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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