HLA-G is upregulated in advanced endometriosis

Marici Rached Rached, Rached MR, Marici R Rached, Verônica Coelho, Maria Lúcia C Marin, Maria Lúcia Carnevale Marin, Marin MLC, Pincerato K, Kátia Pincerato, Kátia Maciel Pincerato, Fujita A, André Fujita, Jorge E Kalil, Jorge Kalil, Maurício S Abrão, Maurício Simões Abrão, Abrão MS
European journal of obstetrics, gynecology, and reproductive biology · 2019 · vol. 235 , pp. 36–41 · doi:10.1016/j.ejogrb.2019.01.030 · PMID:30784825 · W2914415106
article OA: closed CC0 ⤵ 21 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated HLA-G expression in advanced endometriosis and found it to be upregulated in affected tissues.

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Abstract

ObjectiveTo assess whether the HLA-G immunomodulatory protein is potentially involved in the pathophysiology of endometriosis or disease progression.Study designCross-sectional observational study of 227 women who underwent laparoscopy, being 146 for endometriosis excision and 81 for elective tubal ligation (control group). Soluble HLA-G (sHLA-G) levels in the serum and peritoneal fluid (PF), as well as the HLA-G protein expression in matched eutopic and ectopic endometrium of women with and without endometriosis were evaluated by ELISA and immunohistochemistry assays, respectively. Women with endometriosis were separated into groups according to the initial (I/II, n = 60) and advanced (III/IV, n = 86) stages of disease. sHLA-G measurement was performed only in women with matched serum and PF samples in both the control (CTRL; n = 77) and endometriosis (EDT; I-II, n = 60; III-IV, n = 83) groups. HLA-G protein expression was evaluated in 26 women with deep endometriosis (I-II, n = 12; III-IV, n = 14) and 22 controls.ResultsHigher concentrations of sHLA-G (P = 0.013) in the serum but not in the PF were observed in women with advanced endometriosis compared to the control group. In situ expression of HLA-G protein was also higher in ectopic (P = 0.018) but not in eutopic endometrium of women with advanced endometriosis compared to control group.ConclusionOur findings suggest that HLA-G upregulation in advanced stages may contribute to the state of immunosuppression in endometriosis as disease progresses.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis HLA-G Antigens Up-Regulation Adult Ascitic Fluid Ascitic Fluid Cross-Sectional Studies Endometriosis Endometriosis Endometrium Endometrium Female HLA-G Antigens Humans Laparoscopy

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