HLA-G is highly expressed in the serum of patients with adenomyosis

Yunkai Xie, Liu Wei, Zou Yonghui, Wang Fei, Li Changzhong
In: Authorea, Inc. · 2022 · doi:10.22541/au.164864558.81005880/v1 · W4220885559
preprint OA: gold CC0
📄 Open PDF View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found significantly higher serum sHLA-G levels in adenomyosis patients compared to uterine fibroid patients, with levels decreasing after surgery.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Objective To evaluate the expression of soluble human leukocyte antigen G(sHLA-G) in serum of patients with adenomyosis.Methods 34 patients with adenomyosis and 31 patients with uterine fibroids diagnosed histologically were selected as subjects. Serum SHLA-G expression level was detected by enzyme-linked immunosorbent assay (ELISA) in patients with adenomyosis and adenomyoma before and after treatment. while CA125 levels were determined using electrochemiluminescence immunoassay. Results The preoperative serum sHLA-g expression level of the adenomyosis group was significantly higher (18.53 ± 1.435 ng/ml) than that of the fibroids group (28.05 ± 2.466 ng/ml) (P < 0.05). The CA125 level was also significantly higher in patients with adenomyosis than in controls (18.59 ± 1.673 VS 134.8 ± 30.41U/ml; P < 0.05). Serum sHLA-G level in adenomyosis group showed a decreasing trend before and after operation（28.05±14.38 ng/ml、18.41±8.34 ng/ml、14.45±5.77 ng/ml）, serum HLA-G level decreased significantly at 2 days after surgery compared with that before surgery (P < 0.05). sHLA-G decreased more significantly in patients with adenomyosis who underwent total hysterectomy (n=20) than in those who underwent partial hysterectomy (n=14), the sHLA-g level of the patients who underwent total hysterectomy (16.04±4.27ng/ml) was significantly lower than that of the patients who underwent partial hysterectomy (21.79±11.35 ng/ml)(P<0,05).Conclusion Serum sHLA-G is highly expressed in patients with adenomyosis and showed a positive and significant response to therapy. Suggesting that sHLA-G may be closely related to the immune tolerance process of adenomyosis, and is expected to be a serological marker for prognosis assessment of adenomy.

My notes (saved in your browser only)

Condition tags

adenomyosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (22)

Source provenance

europepmc
last seen: 2026-06-11T06:38:44.028908+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK