Serum anti-inflammatory cytokines for the evaluation of inflammatory status in endometriosis

Tudor Drugan, Andrei Mihai Măluţan, AndreiMihai Malutan, Răzvan Ciortea, Radu Florin Mocan-Hognogi, Carmen Elena Bucuri, Carmen Bucuri, Maria Patricia Rada, Dan Mihu
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015 · vol. 20(7) , pp. 668 · doi:10.4103/1735-1995.166215 · PMID:26622256 · PMC4638069 · W2415380425
article OA: gold CC0 ⤵ 29 in-corpus citations
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This study found significantly higher serum levels of IL-1Ra, IL-4, and IL-10 in women with endometriosis compared to controls, suggesting a role for these anti-inflammatory cytokines in the disease.

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Abstract

BACKGROUND: Endometriosis is a frequent gynecologic disease with a severe impact on the quality of life in the affected women; its pathogenesis is yet to be fully understood, with an altered immunity as a possible key factor. The present study aimed to investigate the serum anti-inflammatory cytokine profile in the patients with endometriosis compared with the healthy controls. MATERIALS AND METHODS: One hundred and sixty women were included, divided into two study groups (Group I - endometriosis; Group 2 - healthy women). We evaluated the serum levels of interleukin-1 receptor antagonist (IL-1Ra), IL-2, IL-2R, IL-4, IL-10, IL-13, and IL-15 with the use of Human multiplex cytokine panels. Statistical analyses (normality distribution analysis, independent t-test, Mann-Whitney U-test) were performed using IBM SPSS software (version 22.0) and GraphPad Prism (version 5.00); receiver operating characteristic curve were used to demonstrate the diagnostic performance of the studied markers. RESULTS: The mean serum level of IL-1Ra, IL-4, and IL-10 were significantly higher in women with endometriosis compared to women free of disease from the control group (30.155, 138.459, and 1.489, respectively, compared to 14.109, 84.710, and 0.688, respectively; P < 0.001, P < 0.001, and P = 0.002, respectively.). No significant differences in the mean serum levels of IL-2, IL-13, and IL-15 were observed between the studied groups and IL-2R had a very low detection rate. CONCLUSION: Endometriosis is associated with elevated levels of anti-inflammatory cytokines, IL-1Ra, IL-4, and IL-10, markers that have a potential role as a prognostic factor for endometriosis.

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endometriosis

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