Association between interleukin-10 promoter polymorphisms and endometriosis: A meta-analysis

Fan W, Wei Fan, Shangwei Li, Li S, Chen Q, Qiong Chen, Huang Z, Zhongying Huang, Ma Q, Qianhong Ma, Zhun Xiao, Xiao Z
Gene · 2012 · vol. 515(1) , pp. 49–55 · doi:10.1016/j.gene.2012.11.037 · PMID:23237776 · W2013524048
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This meta-analysis examined the association between interleukin-10 promoter polymorphisms and endometriosis, finding a potential link.

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Abstract

To investigate the influence of the interleukin-10 gene promoter polymorphisms on the susceptibility of endometriosis, we examined the association by performing a meta-analysis. The PubMed, Embase, HuGE Navigator and CNKI were searched to identify eligible studies. We then conducted a meta-analysis to examine the association between interleukin-10 gene promoter polymorphisms and endometriosis. Eight case-control studies which examined the association between the IL-10 gene promoter polymorphisms and the susceptibility to endometriosis were finally included in the meta-analysis. Meta-analysis of the IL-10 -592 A/C polymorphisms showed a significant increased risk of endometriosis in the overall and Asian population in all genetic models and allele contrast. However, meta-analysis of the IL-10 -1082 A/G and IL-10 -819 T/C polymorphisms showed no association with endometriosis in all genetic models and allele contrast in the overall and Asian population samples. In addition, there was not a significant association between the IL-10 -592 A/C gene promoter polymorphisms with the severity of endometriosis. In conclusion, this meta-analysis suggests that the IL-10 -592 A/C polymorphisms conferred susceptibility to endometriosis. However, no associations were found between the IL-10 -1082 A/G and -819 T/C polymorphisms and susceptibility to endometriosis. Further studies are required to elucidate these associations more clearly.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genetic Predisposition to Disease Interleukin-10 Polymorphism, Single Nucleotide Promoter Regions, Genetic Alleles Endometriosis Endometriosis Female Genotype Humans Interleukin-10 Odds Ratio Publication Bias

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (14)

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