Association of an A allele for interleukin-10 -627 gene promoter polymorphism with higher susceptibility to endometriosis.

Yao-Yuan Hsieh, Yao Yuan Hsieh, Hsieh YY, Chang CC, Chi Chen Chang, Chi-Chen Chang, Tsai FJ, Fuu Jen Tsai, Fuu-Jen Tsai, Cheng-Chieh Lin, Lin CC, Cheng‐Chieh Lin, Tai CT, Chin Tao Tai, Chin-Tao Tai, Min Ho, Ho M
The Journal of reproductive medicine · 2003 · vol. 48(9) , pp. 735–8 · PMID:14562641 · W2421853228
article OA: closed CC0 ⤵ 9 in-corpus citations
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This study investigated the IL-10 -627 gene promoter polymorphism and found the A allele to be associated with higher susceptibility to endometriosis in women.

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Abstract

OBJECTIVE: To investigate whether interleukin-10 (IL-10) -627 gene promoter polymorphism could be used as a marker of susceptibility to endometriosis. STUDY DESIGN: Women were divided into 2 groups, endometriosis (n = 130) and nonendometriosis (n = 133). Polymorphisms for IL-10 -627 gene promoter were amplified by polymerase chain reaction and detected after restriction enzyme digestion. Genotypes and allelic frequencies in both groups were compared. RESULTS: Genotype proportions of different IL-10 gene polymorphisms in both groups were not significantly different. Proportions of A homozygote/heterozygote/T homozygote for IL-10 gene polymorphisms in both groups were 50%/40%/10% and 42.1%/38.4%/19.5%. In contrast, allele frequencies for IL-10 gene polymorphism between both groups were significantly different. Alleles A and C for IL-10 gene promoter polymorphism in the groups were 70%/30% and 61.3%/38.7%. A allele was associated with higher susceptibility to endometriosis. CONCLUSION: An association between endometriosis and IL-10 gene promoter polymorphism exists, and the IL-10 -627 A allele is related to a higher susceptibility to endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Alleles Endometriosis Genetic Predisposition to Disease Interleukin-10 Polymorphism, Genetic Promoter Regions, Genetic Deoxyribonucleases, Type II Site-Specific Deoxyribonucleases, Type II Site-Specific Endometriosis Female Gene Frequency Heterozygote Homozygote Humans Interleukin-10 Premenopause Promoter Regions, Genetic

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