Genetic Basis of Endometriosis

Bischoff F, Farideh Bischoff, Farideh Z. Bischoff, Joe Leigh Simpson
Annals of the New York Academy of Sciences · 2004 · vol. 1034(1) , pp. 284–299 · doi:10.1196/annals.1335.030 · PMID:15731320 · W2132229207
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This review discusses heritability studies, genomewide strategies, and candidate genes involved in the genetic basis of endometriosis, a polygenic/multifactorial disorder.

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Abstract

Endometriosis is a complex gynecologic disorder that has long been recognized as showing heritable tendencies, with recurrence risks of 5-7% for first-degree relatives. Familial and epidemiologic studies support that this disease is a genetic disorder of polygenic/multifactorial inheritance. The current investigational challenge is to determine the number and location of causative genes. Recent advances in molecular technology make identification and elucidation of these genes now possible. In this review, we update previous communications in which we also reviewed heritability studies supporting polygenic/multifactorial inheritance, discuss the scientific basis of genomewide strategies for identifying causative genes, and identify potential candidate genes.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Multifactorial Inheritance Oligonucleotide Array Sequence Analysis Endometriosis Female Humans

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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License: CC0 · commercial use OK