Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis

Farahnaz Mardanian, Roshanak Aboutorabi, Yalda Jefride, Guilda Amini
Advanced biomedical research · 2014 · vol. 3(1) , pp. 226 · doi:10.4103/2277-9175.145706 · PMID:25538912 · PMC4260278 · W2060372888
article OA: gold CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found no significant association between TNF alpha gene promoter polymorphisms at -850 T/C and -863 C/A and the risk of developing endometriosis in women.

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Abstract

Background: The purpose of this study was to determine whether variability in gene encoding for promoter of tumor necrosis factor participates to women differences in susceptibility to endometriosis. Materials and Methods: The study involved 130 women; 65 endometriotic and 65 healthy control women. The blood samples were genotyped for -850 T/C and -863 C/A polymorphisms in TNF alpha gene promoter. Chi-square, odd ratio, and confidence interval 95% were used to evaluate genotypes and allele frequency differences between two groups. Results: No significant differences in genotypes distribution of -850 T/C (P = 0.32) and 863 C/A (P = 0.34) polymorphisms were obtained between two groups. Conclusion: According to this study, these two polymorphisms have no risk or protective factor to develop endometriosis.

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endometriosis

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