Endometriosis: Polymorphisms for Interleukin-1β (IL-1β)-511 Promoter, IL-1β Exon 5, and IL-1 Receptor Antagonist: Nonassociation with Endometriosis

Y Y Hsieh, Yao‐Yuan Hsieh, C C Chang, Chi-Chen Chang, F J Tsai, Fuu‐Jen Tsai, J Y Wu, Jer-Yuarn Wu, Yi-Ru Shi, Y R Shi, H D Tsai, Horng-Der Tsai, Chang‐Hai Tsai, C H Tsai
Journal of assisted reproduction and genetics · 2001 · vol. 18(9) , pp. 506–511 · doi:10.1023/a:1016653127262 · PMID:11665666 · W306646258
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Polymorphisms in IL-1β and IL-1Ra genes were investigated for association with endometriosis susceptibility in 120 women with endometriosis and 103 controls, finding no significant differences in genotype or allele frequencies.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The study investigated whether polymorphisms in the interleukin-1β (IL-1β) promoter at -511, IL-1β exon 5, and the IL-1 receptor antagonist (IL-1Ra) gene are associated with endometriosis susceptibility by comparing genotype and allele frequencies between 120 women with endometriosis and 103 controls without endometriosis. Using PCR-based detection of the specified variants, the proportions of genotypes/alleles across both IL-1β and IL-1Ra polymorphisms were nonsignificantly different between groups. The authors concluded that there is no association and that these polymorphisms are not useful predictive markers for susceptibility. This paper is centrally about endometriosis — it tests whether IL-1β (-511 and exon 5) and IL-1Ra polymorphisms are markers of endometriosis susceptibility and finds no association.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Interleukin-1 Polymorphism, Genetic Sialoglycoproteins Asian People Asian People Endometriosis Exons Female Gene Frequency Genetic Markers Genetic Predisposition to Disease Humans Interleukin-1 Interleukin 1 Receptor Antagonist Protein Promoter Regions, Genetic Sialoglycoproteins Taiwan

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