Endometriosis: Polymorphisms for Interleukin-1β (IL-1β)-511 Promoter, IL-1β Exon 5, and IL-1 Receptor Antagonist: Nonassociation with Endometriosis

Purpose: We aimed to investigate if interleukin-1β (IL-1β) and IL-1 receptor antagonist (IL-1Ra) gene polymorphism could be used as markers of susceptibility in endometriosis.

Women were divided into two groups: 1) endometriosis (n = 120); 2) nonendometriosis groups (n = 103). Polymorphisms for IL-1β-511 promoter, IL-1β exon 5, and IL-1Ra were detected by polymerase chain reaction. Genotypes and allelic frequencies for these polymorphisms in both groups were compared.

Proportions of different IL-1 and IL-1Ra polymorphisms in both groups were nonsignificantly different. Proportions of C homozygote/heterozygote/T homozygote for IL-1β-511 promoter in both groups were 1) 21.6/59.1/19.1% and 2) 26.2/50.5/23.3%. Proportions of E1 homozygote/heterozygote/E2 homozygote for IL-1β exon 5 in both groups were 1) 91.6/5/3.3% and 2) 95.15/4.85/0%. Allele I/II/IV/V for IL-1Ra in both groups were 1) 92.5/5.4/ 1.6/0.4% and 2) 95.1/3.9/1/0%.

Association of endometriosis with IL-1β-511 promoter, IL-1β exon 5, and IL-1 receptor antagonist gene polymorphisms doesn't exist. These polymorphisms are not useful markers for prediction of endometriosis susceptibility. Similar content being viewed by others

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