{"paper_id":"d69d24eb-8bc7-4ca7-945f-9ae5a9e62b20","body_text":"Abstract\nPurpose: We aimed to investigate if interleukin-1β (IL-1β) and IL-1 receptor antagonist (IL-1Ra) gene polymorphism could be used as markers of susceptibility in endometriosis.\nMaterials and Methods: Women were divided into two groups: 1) endometriosis (n = 120); 2) nonendometriosis groups (n = 103). Polymorphisms for IL-1β-511 promoter, IL-1β exon 5, and IL-1Ra were detected by polymerase chain reaction. Genotypes and allelic frequencies for these polymorphisms in both groups were compared.\nResults: Proportions of different IL-1 and IL-1Ra polymorphisms in both groups were nonsignificantly different. Proportions of C homozygote/heterozygote/T homozygote for IL-1β-511 promoter in both groups were 1) 21.6/59.1/19.1% and 2) 26.2/50.5/23.3%. Proportions of E1 homozygote/heterozygote/E2 homozygote for IL-1β exon 5 in both groups were 1) 91.6/5/3.3% and 2) 95.15/4.85/0%. Allele I/II/IV/V for IL-1Ra in both groups were 1) 92.5/5.4/ 1.6/0.4% and 2) 95.1/3.9/1/0%.\nConclusions: Association of endometriosis with IL-1β-511 promoter, IL-1β exon 5, and IL-1 receptor antagonist gene polymorphisms doesn't exist. These polymorphisms are not useful markers for prediction of endometriosis susceptibility.\nSimilar content being viewed by others\nREFERENCES\nAkoum A, Jolicoeur C, Boucher A: Estradiol amplifies interleukin-1-induced monocyte chemotactic protein-1 expression by ectopic endometrial cells of women with endometriosis. J Clin Endocrinol Metab 2000;85:896-904\nPellicer A, Albert C, Mercader A, Bonilla-Musoles F, Remohi J, Simon C: The follicular and endocrine environment in women with endometriosis: Local and systemic cytokine production. Fertil Steril 1998;70:425-431\nCarlberg M, Nejaty J, Froysa B, Guan Y, Soder O, Bergqvist A: Elevated expression of tumour necrosis factor alpha in cultured granulosa cells from women with endometriosis. 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J Assist Reprod Genet 18, 506–511 (2001). https://doi.org/10.1023/A:1016653127262\nIssue date:\nDOI: https://doi.org/10.1023/A:1016653127262","source_license":"CC0","license_restricted":false}