Evaluation of germline sequence variants within the promoter region of RANTES gene in a cohort of women with endometriosis from Spain

G Antiñolo, Guillermo Antiñolo, R M Fernández, J A Noval, J C García-Lozano, S Borrego, I Marcos, J L Moliní
Molecular human reproduction · 2003 · vol. 9(8) , pp. 491–495 · doi:10.1093/molehr/gag057 · PMID:12837926 · W2113130400
article OA: bronze CC0 ⤵ 6 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study genotyped promoter variants in the RANTES gene in Spanish women with endometriosis and found no association with the disease.

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Abstract

The RANTES (regulated upon activation normal T cells expressed and secreted) chemokine, is known to be expressed in endometriotic lesions in a concentration correlating with the severity of endometriosis. Since it has been widely demonstrated that endometriosis has a genetic basis, we postulated that the gene encoding RANTES could be a good candidate gene for the disease. We have used fluorescence resonance energy transfer (FRET) technology to genotype and evaluate the role of the variants -403G-->A and -28C-->G, located within the promoter region of the gene, as susceptibility factors in a cohort of Spanish women with endometriosis. No differences have been found in the allelic frequencies of both variants nor in the haplotype/ genotype distribution between patients and controls. These data are consistent with the lack of association between these polymorphisms and endometriosis in our population. They do not exclude completely a possible role of other variants within RANTES gene in this pathology.

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Condition tags

endometriosis

MeSH descriptors

Chemokine CCL5 Endometriosis Polymorphism, Genetic Promoter Regions, Genetic Adult Base Sequence Chemokine CCL5 Cohort Studies Endometriosis Endometriosis Female Fluorescence Resonance Energy Transfer Genotype Humans Middle Aged Molecular Sequence Data Point Mutation Spain

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