Endometriosis in monozygotic twins
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Six of eight monozygotic twin sisters with endometriosis also had the condition, suggesting a strong genetic component for endometriosis.
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Abstract
OBJECTIVE: To study the reproductive and medical history of monozygotic twin sisters and mothers of patients with endometriosis. MATERIAL AND METHODS: Among 515 patients with endometriosis, eight had a monozygotic twin sister all of whom had had a gynecological laparoscopy or laparotomy. In addition, five of their mothers had had a laparotomy. Details about these 13 relatives were obtained either from medical records (ten cases) or by unmistakable reports from the proband (three cases). RESULT: Six of the monozygotic twin sisters (75%) also had symptomatic endometriosis compared with 3.8% among other types of sisters (p < 0.0005). Three of the mothers (38%) had either endometriosis or adenomyosis. CONCLUSION: This study gives support to the assumption that endometriosis has a genetic trait.
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- ‘Nobody really knows what it is or how to treat it’: Why women with endometriosis do not comply with healthcare advice 2009
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- No association of endometriosis with galactose‐1‐phosphate uridyl transferase mutations in a Chinese population 2006
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