[Endometriosis: aetiopathogenetic basis].

M Larosa, Michelangelo Larosa, Francesco Facchini, F Facchini, G Pozzoli, M Leone, Marco Leone, M Grande, B Monica
Urologia · 2011 · vol. 77 Suppl 17 , pp. 1–11 · PMID:21308668 · W169429271
article OA: closed CC0 ⤵ 11 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper reviews endometriosis, a condition affecting 10% of reproductive-age women, focusing on theories of retrograde menstruation, immunological factors, and angiogenesis in its pathogenesis.

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Abstract

Endometriosis, defined by the presence of endometrial tissue outside the uterine cavity, is a common condition affecting 10% of women in the reproductive age. Menstrual factors reported to increase risk include dysmenorrhea, early menarche, and shorter cycle lengths. The theory of retrograde menstruation with implantation of endometrial fragments, in conjunction with peritoneal factors to stimulate cell growth is the most widely accepted. There is a growing body of evidence that immunological factors and angiogenesis play a key role in the pathogenesis of endometriosis. In women with endometriosis, there appears to be an alteration in the function of peritoneal macrophages, natural killer cells and lymphocytes, with production of growth factors and inflammatory mediators in the peritoneal fluid. Survival, adhesion, proliferation, invasion and vascularization of endometrial tissue in abdominal cavity may be the consequence of retrograde menstruation and referred to as implantation theory.

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Condition tags

mesh:D004715endometriosisdysmenorrhea

MeSH descriptors

Endometriosis Ascitic Fluid Ascitic Fluid Cell Adhesion Cytokines Cytokines Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Estrogens Estrogens Female Humans Inflammation Mediators Inflammation Mediators Intercellular Signaling Peptides and Proteins Intercellular Signaling Peptides and Proteins Iron

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (95)

Cited by (11)

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License: CC0 · commercial use OK