Soluble ST2 and IL-33: Potential markers of endometriosis in the Tunisian population

Maroua Mbarik, Mbarik M, Wajih Kaabachi, Kaabachi W, Henidi B, Balkis Henidi, Fayçal Haj Sassi, Faycal Haj Sassi, Sassi FH, Kamel Hamzaoui, Hamzaoui K
Immunology letters · 2015 · vol. 166(1) , pp. 1–5 · doi:10.1016/j.imlet.2015.05.002 · PMID:25977120 · W289750203
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This study investigated soluble ST2 and IL-33 as potential biomarkers for endometriosis in Tunisian women, assessing their diagnostic value.

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Abstract

Interleukin-33 is an IL-1 family cytokine which signals via its T1/ST2 receptor, and acts as a key regulator of inflammation. This study aims to measure the expression of soluble ST2 (sST2) and IL-33 in endometriosis. We investigated thirty women with laparoscopic and histopathological confirmed endometriosis and 20 control women without pelvic pathology. Peripheral blood mononuclear cells and peritoneal fluid (PF) were assessed for sST2 and IL-33 levels that are measured by sandwich enzyme-linked immunosorbent assay. Peritoneal fluid IL-33 mRNA expression was quantified by real-time reverse transcription polymerase chain reaction assays. We found that IL-33 levels in PF and in serum were significantly higher in patients with endometriosis compared to women without endometriosis (P < 0.05). IL-33 increased levels were significantly more important in PF [10.45 ± 14.33 ng/mL] than in serum [2.68 ± 1.54 ng/mL] from endometriosis patients. Higher levels of IL-33 mRNA expression were detected in PF from patients with endometriosis. Soluble ST2 levels in PF were significantly different between patients [2.96 ± 0.98 ng/mL; P 0.05). Significant correlation was observed between IL-33 and sST2 levels in PF. In conclusion, IL-33 and sST2 values observed in PF were found to correlate with endometriosis severity. Elevated and correlated PF IL-33 and sST2 levels from patients with endometriosis suggested a potential role as surrogate markers of disease activity.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Interleukin-33 Leukocytes, Mononuclear Receptors, Cell Surface Ascitic Fluid Biomarkers Biomarkers Biomarkers Endometriosis Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Female Humans Inflammation Interleukin-1 Receptor-Like 1 Protein Interleukin-33 Interleukin-33 Interleukin-33

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