Endometriosis-Search for Biomarkers

Milena Králíčková, Václav Větvička
In: American Journal of Immunology · 2016 · vol. 12(2) , pp. 43–48 · doi:10.3844/ajisp.2016.43.48 · W2518880182
article OA: diamond CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This review examines current research on endometriosis biomarkers, concluding that despite extensive efforts, no specific, noninvasive marker has yet enabled timely diagnosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This 2016 review by Kralíčková and Větvická surveys prior research on noninvasive diagnostic biomarkers for endometriosis, focusing on tumor markers such as CA125/CA19-9 and related markers (including HE4 and CA72-4), as well as microRNAs, mRNA-related findings, genetic alterations, and immunological markers. Across the discussed studies, CA125 and CA19-9 (sometimes combined with markers like IL-6 or hsCRP and potentially alongside HE4) show diagnostic associations, while microRNA expression patterns in plasma have been reported as potentially specific biomarkers; however, the authors emphasize that sensitivity and specificity remain insufficiently low and that no clinically applicable test is available. A major limitation highlighted throughout is the lack of consistent specificity across markers and the continuing uncertainty about biological significance and diagnostic performance. This paper is centrally about endometriosis — it reviews the current search for noninvasive diagnostic biomarkers (e.g., CA125 and microRNAs) and concludes that a validated clinical test is still missing.

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Abstract

Numerous studies are seeking noninvasive methods to diagnose endometriosis, but a clinically applicable test is still missing. Current paper compares the current results in our search for the best diagnostic marker. We summarize that despite the extensive research on endometriosis biomarkers, timely diagnosis using specific biomarkers remains an unfilled dream.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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