Endometriosis and Cancer

Milena Králíčková, Petr Losan, Petr Lošan, Vaclav Vetvicka, Václav Větvička
Women's health (London, England) · 2014 · vol. 10(6) , pp. 591–597 · doi:10.2217/whe.14.43 · PMID:25482486 · W2132892316
review OA: gold CC0 ⤵ 27 in-corpus citations
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Histological and genetic alterations in endometriosis may explain its conversion into several types of cancer, though exact mechanisms remain unclear.

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Abstract

Endometriosis is manifested by the presence of both endometrial glandular and stromal cells outside the uterine cavity. It is characterized by ectopic implantation of endometrial cells with elevated proliferation and migration. Endometriosis is the leading cause of morbidity among premenopausal women and the complex pathogenesis of this disease remains controversial despite extensive research. This rather complex disease has a significant impact on quality of life of many women as none of the current treatments represent a cure. Based on the current knowledge, one can conclude that the histological and genetic alterations in endometriosis might explain why and how endometriosis can change into several types of cancer. However, the exact mechanisms of this conversion are still not fully established.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Ovarian Neoplasms Endometriosis Female Humans Ovarian Neoplasms Stem Cells Stem Cells

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (59)

Cited by (27)

Source provenance

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