Role of connexins in female reproductive system and endometriosis

Kaushik T, Tripti Kaushik, Rakesh Mishra, Mishra R, Rakesh K Singh, Rakesh Kumar Singh, Singh RK, Surabhi Bajpai
Journal of gynecology obstetrics and human reproduction · 2020 · vol. 49(6) , pp. 101705 · doi:10.1016/j.jogoh.2020.101705 · PMID:32018041 · W3003786021
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This paper reviews the role of connexins in the female reproductive system and their involvement in the development and progression of endometriosis.

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Abstract

Gap junction form channels between the cells and facilitate the function of cellular cross talk. Connexins, the gap junction proteins play an essential role in female reproductive health and its expression anomalies are correlated with female reproductive disorders like polycystic ovarian syndrome, recurrent miscarriage, pre-term birth and endometriosis. Endometriosis is a chronic gynecologic disorder caused by ectopic endometrial lesions growing outside the uterine cavity. Embryonic implantation is adversely affected in case of endometriosis leading to infertility. Endometriosis also interferes with ovulatory functions, reduces fertilization and impaires blastocyst implantation. There lies a lacunae in understanding of the role of gap junctions protein connexins in endometriosis. Therefore, this study discusses the role of connexins in improving female fertility by taming the processes of oogenesis, germ line development, uterine receptivity, placental growth, implantation, decidualization and concludes by focusing the role of connexins in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Connexins Endometriosis Genitalia, Female Connexins Decidua Decidua Embryo Implantation Embryo Implantation Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Gap Junctions Gap Junctions Genitalia, Female Humans Infertility, Female Infertility, Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (59)

Cited by (1)

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License: CC0 · commercial use OK