Whole genome deoxyribonucleic acid microarray analysis of gene expression in ectopic versus eutopic endometrium

Eyster KM, Kathleen M Eyster, Klinkova O, Olga Klinkova, Vanessa Kennedy, Kennedy V, Vanessa E. Kennedy, Hansen KA, Keith A Hansen
Fertility and sterility · 2007 · vol. 88(6) , pp. 1505–1533 · doi:10.1016/j.fertnstert.2007.01.056 · PMID:17462640 · W2052036741
article OA: bronze CC0 ⤵ 134 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study analyzed gene expression in ectopic versus eutopic endometrium using whole genome DNA microarrays to identify differential expression patterns.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo use DNA microarrays to identify differentially expressed genes in eutopic endometrium compared with ectopic endometrium.DesignProspective, cross-sectional, observational study.SettingUniversity Medical Center and Research Laboratory.Patient(s)Eleven women with endometriosis.Intervention(s)None.Main outcome measure(s)Differential gene expression.Result(s)Seven hundred seventeen of the 53,000 probes on the whole human DNA microarrays were changed by twofold or greater in ectopic versus eutopic endometrium. Families of genes that were expressed differentially include genes that code for proteins associated with the immune system and inflammatory pathways, cell adhesion, cell-cell junctions, the extracellular matrix and its remodeling, cytoskeletal proteins, and signal transduction pathway components, among others.Conclusion(s)The altered immune environment may allow survival of endometriotic cells that enter the abdominal cavity. Alterations of cell adhesion-associated genes may contribute to the adhesive and invasive properties of ectopic endometrium, and changes in signal transduction pathways support a change in the communication among cells of the endometrial explant compared with eutopic endometrium. These families of differentially expressed genes provide multiple opportunities for the development and testing of new hypotheses regarding endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Gene Expression Profiling Genome, Human Oligonucleotide Array Sequence Analysis Peritoneal Diseases Adult Cross-Sectional Studies DNA DNA Endometriosis Endometriosis Endometrium Female Humans Middle Aged Peritoneal Diseases Peritoneal Diseases Prospective Studies

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (56)

Cited by (50)

Source provenance

europepmc
last seen: 2026-07-25T06:15:30.875455+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:15:00.519696+00:00
License: CC0 · commercial use OK