Regulation of angiogenesis in the endometrium

S. K. Smith, Smith SK
Trends in endocrinology and metabolism: TEM · 2001 · vol. 12(4) , pp. 147–151 · doi:10.1016/s1043-2760(01)00379-4 · PMID:11295569 · W2091206431
review OA: closed CC0 ⤵ 59 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This paper investigates the regulatory mechanisms of blood vessel formation within the endometrium.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

A crucial stage in pregnancy is the implantation of the embryo into the endometrium. The endometrium, which is situated in the lining of the uterus, is a complex structure consisting of a single epithelial layer overlying a mesenchymal stroma. Cyclical growth of the endometrium under the influence of ovarian steroids results in the establishment of a receptive endometrium. If implantation fails, or is deliberately prevented by the use of fertility regulation, the endometrium is shed by the process of menstruation. This unique system of cyclic tissue regeneration is dependent on the cyclical growth and regression of the blood vessels that supply the endometrium. Little attention has been paid to this crucial aspect of human reproduction but it now appears that many disorders that reduce the quality of life of modern women, such as heavy menstruation, endometriosis, breakthrough bleeding and infertility, might have their basis in disorders of the endometrial vasculature.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometrium Homeostasis Neovascularization, Physiologic Endometriosis Endometriosis Endometrium Endothelial Growth Factors Endothelial Growth Factors Female Humans Lymphokines Lymphokines Menstrual Cycle Pregnancy Uterine Hemorrhage Uterine Hemorrhage Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (70)

Cited by (50)

Source provenance

europepmc
last seen: 2026-07-31T06:09:14.520117+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:13:24.901228+00:00
License: CC0 · commercial use OK