Serum salusins levels are increased and correlated positively with cyst size in ovarian endometrioma

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Serum salusin-α and salusin-β levels are significantly elevated in women with ovarian endometrioma, correlating positively with cyst size, and decrease to normal levels after surgical removal.

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Abstract

OBJECTIVES: The objective of this study is to evaluate plasma concentrations of salusin-α and salusin-β levels in women with endometrioma and non-endometriotic benign ovarian cysts. METHOD: Endometrioma patients (n = 14), non-endometriotic ovarian cysts (n = 14), and age-matched normal healthy fertile subjects (n = 14) participated in this study. Plasma salusin-α and salusin-β levels at the time of mid-luteal phase before and 3 months after L/S cystectomy were measured using ELISA and EIA tests, and their relation with demographic parameters was also assessed. RESULTS: The mean salusin-α and salusin-β levels were significantly higher in women with endometrioma before the removal of cyst compared with cases with non-endometriotic cyst and fertile cases. Surgical removal of the endometrioma decreased the mean salusin-α and salusin-β levels to the level of those with non-endometriotic cyst before and after the cystectomy and fertile women, in both unilateral and bilateral endometrioma cases. Plasma salusin-β concentrations were found to be positively correlated with age, size of cyst, bilaterality, and salusin-α levels. Salusin-β values showed no correlations to BMI and size of the ovarian cysts. CONCLUSIONS: Plasma salusin-α and salusin-β levels are increased in endometrioma patients and positively correlated with endometrioma size. Laparoscopic removal of the endometrioma by stripping technique decreases the salusin levels to a similar level of fertile women.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Intercellular Signaling Peptides and Proteins Ovarian Cysts Ovarian Diseases Adult Endometriosis Endometriosis Female Humans Intercellular Signaling Peptides and Proteins Ovarian Cysts Ovarian Cysts Ovarian Diseases Ovarian Diseases

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europepmc
last seen: 2026-06-13T06:22:48.782012+00:00
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