Die Bedeutung der Angiogenese für die Pathogenese der Endometriose

D M Gescher, Dorothee Maria Gescher, A Haensel, A Meyhöfer-Malik, Eduard Malik, E Malik
Zentralblatt fur Gynakologie · 2003 · vol. 125(07/08) , pp. 243–246 · doi:10.1055/s-2003-42278 · PMID:14505257 · W2395073134
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Angiogenesis in ectopic endometrium is crucial for endometriosis pathogenesis and lesion activity, as shown by VEGF and MMP mRNA expression correlating with vascularity in a CAM assay.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

The paper discusses how implantation of ectopic endometrial tissue is a key step in endometriosis pathogenesis and argues that angiogenesis is both a prerequisite for implantation and a parameter reflecting lesion activity. Using a chorioallantoic membrane (CAM) assay model with ectopic endometrial fragments, the authors analyzed time-dependent mRNA expression of VEGF and matrix metalloproteinases MMP1 and MMP2 and correlated these molecular changes with angiogenesis assessed by a vessel density index. They report an increase in angiogenic factors and an increase in angiogenic reaction over time, implying a link between angiogenic signaling and implanting aggressiveness. The study’s main limitation is that these findings are derived from an experimental CAM model rather than directly from human lesions in vivo. This paper is centrally about endometriosis — it focuses on how angiogenesis (VEGF/MMP-related activity) supports implantation and lesion activity in the pathogenesis of endometriosis.

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Abstract

The pathogenesis of endometriosis is dependent on implantation. Therefore, angiogenesis of the ectopic endometrium is discussed as a crucial step in the development of an endometriotic lesion. It is not only the main condition for implantation, but also a parameter for the clinical activity of endometriosis. Pigmented and non-pigmented endometriotic lesions differ according to their clinical activity and angiogenic potential. Using a model system of endometriosis, the chorioallantoic membrane assay, mRNA expression of VEGF and matrix metalloproteinases 1 and 2 was analysed. As the most representative angiogenic factors, they were correlated to the angiogenic reaction on the CAM by the vessel index. We assume that angiogenic activity of ectopic endometrium is a condition sine qua non for the pathogenesis of endometriosis, but is regulated by different other factors.

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Condition tags

endometriosisdie_deep_infiltrating

MeSH descriptors

Endometriosis Neovascularization, Pathologic Disease Progression Endometriosis Endometriosis Endometriosis Female Humans Matrix Metalloproteinase 1 Matrix Metalloproteinase 1 Matrix Metalloproteinase 2 Matrix Metalloproteinase 2 Neovascularization, Pathologic Neovascularization, Pathologic RNA, Messenger RNA, Messenger Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor A

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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