Eduard Malik

OBJECTIVE: To evaluate the possible associations between serum endocan levels and endometriosis. STUDY DESIGN: A total of 60 women with histologically proven endometriosis and 40 women who underwent laparoscopy due to unexplained infertilit…

ObjectiveTo evaluate the possible associations between serum endocan levels and endometriosis. Study DesignA total of 60 women with histologically proven endometriosis and 40 women who underwent laparoscopy due to unexplained infertility w…

Considering the complex pathogenesis of endometriosis, which is associated with many cellular or molecular processes, such as proliferation, angiogenesis, inflammation, we evaluated the diagnostic value of a quadruple panel of serum markers…

Objective: To evaluate the possible associations between serum 25-hydroxy vitamin D levels and clinical and laboratory parameters in endometriosis.Study design: A total of 53 women with endometriosis and 37 women without endometriosis were …

The term "deciduosis" is used to describe the severe pregnancy-associated occurrence of ectopic decidua with a usually asymptomatic course. We report on two cases of massive maternal intra-abdominal bleeding due to such symptomatic changes.…

Abstract in English \nThe term "deciduosis" is used to describe the severe pregnancy-associated occurrence of ectopic decidua with a usually asymptomatic course. We report on two cases of massive maternal intra-abdominal bleeding due to suc…

BackgroundThe role of estrogen receptor beta (ERβ) in pathogenesis of endometriosis remains to be elucidated. In this study, we have examined the expression of the four main ERβ transcript isoforms in human endometrial tissue in women with …

OBJECTIVE: To investigate the role of matrix metalloproteinase 1 and 2 (MMP-1/MMP-2) in human endometrial explants in a chicken chorioallantoic membrane model (CAM) of endometriosis. DESIGN: Experimental prospective study. SETTING: Univer…

AimEndometriosis is a frequent benign disease of women in reproductive age. An infiltration of the spatium rectovaginal is rare, but if it occurs, in up to 73% the rectum is involved. If there is the indication for surgery, a partial resect…

In der Endometrioseforschung gilt die Chorioallantoismembran (CAM) als mögliches Modell zum Studium der Implantation des Endometriums. Eine wichtige Voraussetzung für die Implantation ist die Angiogenese, welche einer komplexen Steuerung du…

Fragestellung: Die CAM ist ein mögliches Modell zum Studium der Implantation des Endometriums. Anfänglich kommt es zur Aussprossung neuer Gefäße, die ab dem 11. Bebrütungstag überwiegend ein Breitenwachstum zeigen. Untersucht wurde die Gefä…

Die CAM ist ein mögliches Modell zum Studium der Implantation des Endometriums. Anfänglich kommt es zur Aussprossung neuer Gefäße, die ab dem 11. Bebrütungstag überwiegend ein Breitenwachstum zeigen. Untersucht wurde die Gefäßdichte und die…

Study objectiveTo evaluate the observer's influence on the diagnosis and classification of endometriosis according to the rASRM classification.Design: Prospective analysis.SettingUniversity hospital.PatientsDigital videotapes of laparoscopi…

BackgroundIn endometriosis, angiogenesis is a crucial step for implantation of the exfoliates. A priori potential to induce angiogenesis by vascular endothelial growth factor (VEGF) expression was compared in eutopic endometrium of patients…

OBJECTIVE: To investigate the role of angiopoietin 1 and 2 (ANGPT1/ANGPT2) in angiogenesis of the ectopic endometrium as a crucial step in the development of an endometriotic lesion, we analyzed their expression patterns in an experimental …

BACKGROUND: Malignant transformation in endometriosis is a rare but well known complication. However, detailed mechanisms of malignant transition and tumourigenesis in endometriosis remain unknown. We here describe the case of an endometrio…

ObjectiveTo analyze the expression of angiopoietin 1 (ANGPT1) in pigmented and nonpigmented endometriosis implants and specify its role in the interaction of angiogenic factors.DesignExperimental retrospective study.SettingUniversity hospit…

Zielsetzung: Matrix Metalloproteinasen (MMP) gelten als Schlüsselenzyme im Prozess des extrazellulären Remodellings. In einem differenzierten System sind sie an der embryonalen Entwicklung und morphologischen Vorgängen wie Wundheilung und A…

The pathogenesis of endometriosis is dependent on implantation. Therefore, angiogenesis of the ectopic endometrium is discussed as a crucial step in the development of an endometriotic lesion. It is not only the main condition for implantat…

According to the transplantation theory, endometriosis develops from endometrial fragments that are retrogradely menstruated into the peritoneal cavity. In order to develop into endometriotic lesions, they have to connect to the vascular sy…

Entscheidend für die Pathogenese der Endometriose ist der Implantationsprozess von ektopen Endometriumzellen an der Peritonealoberfläche. Den pathophysiologischen Mechanismus der Implantation stellt dabei die Angiogenese dar. Diese wird dur…