A priori implantation potential does not differ in eutopic endometrium of patients with and without endometriosis

D M Gescher, Dorothee Maria Gescher, Wulf Siggelkow, W Siggelkow, A Meyhoefer-Malik, Annette Meyhoefer-Malik, E Malik, Eduard Malik
Archives of gynecology and obstetrics · 2004 · vol. 272(2) , pp. 117–123 · doi:10.1007/s00404-004-0688-9 · PMID:15986219 · W1967673779
article OA: closed CC0 ⤵ 10 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This study compared VEGF expression and angiogenic induction in eutopic endometrial fragments from endometriosis patients and controls transplanted to a chicken chorioallantoic membrane, finding no significant differences.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This experimental prospective study compared angiogenic induction potential, focusing on VEGF mRNA expression and protein localization, in eutopic endometrial tissue from 10 women with endometriosis versus 6 healthy, ovulating controls, using endometrial fragments transplanted onto the chicken chorioallantoic membrane (CAM) and re-cultured for 0–96 hours. VEGF mRNA rose significantly in endometrial fragments from both groups, with VEGF protein expressed in glands and stroma, and vessel index increased versus native CAM controls. However, endometriosis and control samples showed no significant differences in VEGF expression or angiogenic induction in the CAM assay. A key limitation is the small sample size and that the CAM transplantation model may reflect only part of the implantation process, with the authors concluding implantation may be driven by external regulating influences on exfoliated endometrial tissue. This paper is centrally about endometriosis — it tests whether eutopic (in-patient) endometrium differs in VEGF-mediated implantation/angiogenic potential between women with and without endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometrium Animals Chick Embryo Chorioallantoic Membrane Chorioallantoic Membrane Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Female Humans Immunohistochemistry Neovascularization, Pathologic Neovascularization, Pathologic Neovascularization, Physiologic Neovascularization, Physiologic Prospective Studies

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License: CC0 · commercial use OK