Models of Endometriosis:In vitroandIn vivoModels

Ruth Grümmer

doi:10.1002/9781444398519.ch25

Models of Endometriosis:In vitroandIn vivoModels

Ruth Grümmer

In: Endometriosis · 2011 · pp. 263–269 · doi:10.1002/9781444398519.ch25 · W1500469056

other OA: closed CC0 ⤵ 5 in-corpus citations

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This chapter reviews the in vitro and in vivo experimental models, including autotransplantation and xenotransplantation methods, used to study the complex pathogenesis of endometriosis and develop novel therapies.

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Abstract

The development of endometriosis is a complex and multifactorial process, and decoding of its pathogenesis is challenging. To evaluate fundamental mechanisms involved in the establishment of this disease as well as to develop novel therapeutical approaches, sophisticated experimental models have been established. These range from simplistic in vitro models permitting easy manipulation of cells to animal models which allow the evaluation of more complex interactions. Animal models have been developed by autotransplantation of endometrial tissue to rodents or non-human primates, and by xenotransplantation of human endometrium to immunodeficient mice. This chapter will give a summarizing overview of the in vivo and in vitro models used for the study of endometriosis.

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endometriosis

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