Luminescence as a Tool to Assess Pelvic Endometriosis Development in Murine Models

Sylvie Defrère, Sébastien Colette, Jean-Christophe Lousse, Jean‐Christophe Lousse, Jacques Donnez, Anne Van Langendonckt
Reproductive sciences (Thousand Oaks, Calif.) · 2009 · vol. 16(12) , pp. 1117–1124 · doi:10.1177/1933719109335069 · PMID:19380902 · W1983720219
review OA: closed CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Luminescence techniques, using genetically modified or dye-labeled endometrium, are valuable for identifying, visualizing, and quantifying endometriotic transplants in murine models.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

The paper reviews and conceptualizes luminescence-based approaches to measure endometriotic lesion development in murine models, focusing on the challenge that small, tissue-embedded implants can make lesion identification and quantification difficult when assessing therapeutic effects. It describes transplanting luminescently labeled murine or human endometrium into animals, using either genetically modified endometrial tissue or fluorescent dye labeling, and highlights how luminescence enables visualization/quantification as well as endometrial cell tracking with spatial and temporal information in vivo. A key caveat is that the choice between labeling strategies depends on study goals and design, including whether experiments are short- or long-term and whether models are homologous or heterologous. This paper is centrally about endometriosis — it focuses on luminescence tools to assess pelvic endometriosis development in murine models.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Fluorescent Dyes Genes, Reporter Luminescent Measurements Luminescent Proteins Staining and Labeling Animals Disease Models, Animal Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Humans Luminescent Proteins Luminescent Proteins Mice Mice, Transgenic

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References (44)

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europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
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License: CC0 · commercial use OK