Transplantation of normal and ectopic human endometrial tissue into athymic nude mice

Zamah NM, Nezaam M. Zamah, N M Zamah, Melvin G. Dodson, M G Dodson, Dodson MG, L C Stephens, Stephens LC, L. Clifton Stephens, Buttram VC Jr, V C Buttram, Veasy C. Buttram, Paige K. Besch, Besch PK, P K Besch, R H Kaufman, Raymond H. Kaufman, Kaufman RH
American Journal of Obstetrics and Gynecology · 1984 · vol. 149(6) , pp. 591–597 · doi:10.1016/0002-9378(84)90240-0 · PMID:6742039 · W2003474149
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study transplanted normal and ectopic human endometrial tissue into athymic nude mice to observe their behavior in a host environment.

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Abstract

Implants or tiny circumscribed nodules of endometrial tissue were found in all female mice given intraperitoneal injections of fragments of human normal (proliferative and secretory) or ectopic (endometrioma) endometrium. Half of these animals received estrogen supplementation and the other half received none. The endometriosis tissue present in these animals at 28 or 56 days after inoculation consisted of glands and stroma with an infiltration of hemosiderin-laden macrophages. Glands in tissue transplants of animals given supplemental estrogen tended to be larger, and the secretory endometrium tended to revert to a proliferative pattern. Palpable nodules at the site of subcutaneous inoculations of proliferative endometrium became undetectable grossly and microscopically within 24 to 32 days, whereas endometrioma tissue remained detectable for up to 70 days and resembled the intraperitoneal tissue microscopically. This study demonstrates that human endometrial tissue can be successfully transplanted into the nude mouse and will retain its basic morphology.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Peritoneal Neoplasms Animals Cecal Neoplasms Cecal Neoplasms Endometriosis Endometrium Endometrium Endometrium Estradiol Estradiol Female Humans Mice Mice, Nude Peritoneal Neoplasms

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References (15)

Cited by (50)

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License: CC0 · commercial use OK