Endometriosis research: animal models for the study of a complex disease

Tirado-González I, Irene Tirado-González, Irene Tirado‐González, Gabriela Barrientos, Nadja Tariverdian, Tariverdian N, Arck PC, Petra Arck, Petra C Arck, Mariana G García, Mariana Garcı́a, Klapp BF, Burghard F Klapp, Sandra M. Blois
Journal of Reproductive Immunology · 2010 · vol. 86(2) , pp. 141–147 · doi:10.1016/j.jri.2010.05.001 · PMID:20594597 · W2074012140
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This review surveys existing animal models utilized for studying endometriosis, highlighting their strengths and limitations in investigating this complex gynecological disorder.

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Abstract

Endometriosis is a common gynaecological disease that is characterized and defined as the presence of endometrial tissue outside the uterus, causing painful periods and subfertility in approximately 10% of women. After more than 50 years of research, little is known about the mechanisms underlying the development and establishment of this condition. Animal models allow us to study the temporal sequence of events involved in disease establishment and progression. Also, because this disease occurs spontaneously only in humans and non-human primates and there are practical problems associated with studying the disease, animal models have been developed for the evaluation of endometriosis. This review describes the animal models for endometriosis that have been used to date, highlighting their importance for the investigation of disease mechanisms that would otherwise be more difficult to elucidate, and proposing new alternatives aimed at overcoming some of these limitations.

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Condition tags

endometriosis

MeSH descriptors

Disease Models, Animal Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Animals Biomedical Research Biomedical Research Biomedical Research Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (56)

Cited by (50)

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License: CC0 · commercial use OK