Microarray analysis provides insight into the early steps of pathophysiology of mouse endometriosis model induced by autotransplantation of endometrium

Umezawa M, Masakazu Umezawa, Naomi Tanaka, Tanaka N, Hitoshi Tainaka, Tainaka H, Takeda K, Ken Takeda, Ihara T, Tomomi Ihara, Sugamata M, Masao Sugamata
Life sciences · 2009 · vol. 84(23-24) , pp. 832–837 · doi:10.1016/j.lfs.2009.03.015 · PMID:19345696 · W2152847018
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This study used microarray analysis to investigate the early pathological changes in a mouse model of endometriosis created by autotransplantation of endometrium.

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Abstract

AimsTo characterize the biochemical alterations that occur in the peritoneal tissue of the mouse endometriosis model during early development of the lesion using microarray analysis.Main methodsThe endometriosis model was induced by autotransplantation of endometrium in 8-week-old female ICR mice. Peritoneum only (excluding the transplant) was obtained 24, 48, and 96 h after the autotransplantation and subjected to microarray analysis. To interpret the large amounts of data generated and to enable a functional analysis, genes were classified using Gene Ontology (GO) and Medical Subject Heading (MeSH) terms, and the results were compared with previous reports on endometriosis.Key findingsOf the upregulated genes, those involved in the inflammatory response, cell adhesion, extracellular matrix, wound healing, hormones, and leukocytes were significantly enriched 24 and 48 h after autotransplantation. Those of cytokines, antibody-producing cells, dendritic cells, inflammation, and infertility were enriched after 96 h. Analysis using GO and MeSH provided different information. Particularly, MeSH showed a link between an anatomical and diseased phenotype with common genes found to be upregulated.SignificanceThe factors occurring during early development of endometriosis induced by endometrium autotransplantation are increase in adhesion molecules and inflammatory responses rather than angiogenesis. Data presented herein may reveal a novel therapeutic gene targets and will contribute to knowledge for the treatment of this currently incurable disease.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometrium Endometrium Oligonucleotide Array Sequence Analysis Oligonucleotide Array Sequence Analysis Animals Disease Models, Animal Endometriosis Endometriosis Endometrium Endometrium Female Mice Mice, Inbred ICR Transplantation, Autologous

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