Highly Stable and Bright NIR-II AIE Dots for Fluorescence Imaging-Guided Photothermal Ablation of Endometriosis

Advanced Hub Main Navigation Menu Highly Stable and Bright NIR-II AIE Dots for Fluorescence Imaging-Guided Photothermal Ablation of Endometriosis Zhihui Huang Center of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036 P. R. China Institute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036 P. R. China Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, 518036 P. R. China Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China Search for more papers by this authorJinju Lin Center of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036 P. R. China Institute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036 P. R. China Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, 518036 P. R. China Search for more papers by this authorXiaojun Wang Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, P. R. China Search for more papers by this authorJiqiang Liu Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China Search for more papers by this authorChunyi Zhou China Railway Lanzhou Group Co., Ltd, Lanzhou, 518024 P. R. China Search for more papers by this authorQingqing Zhang Stem Cell & Regenerative Medicine Consortium, School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, 5/F, Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road, Hong Kong, P. R. China Centre for Translational Stem Cell Biology, 17 W Science Park, Hong Kong SAR, P. R. China Search for more papers by this authorPing Gong Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China Search for more papers by this authorLintao Cai Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China Sino-Euro Center of Biomedicine and Health, Shenzhen, 518024 P. R. China Search for more papers by this authorCorresponding Author Pengfei Zhang Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China E-mail: [email protected]; [email protected]; [email protected] Search for more papers by this authorCorresponding Author He Zhang Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044 P. R. China E-mail: [email protected]; [email protected]; [email protected] Search for more papers by this authorCorresponding Author Huashan Zhao Center of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036 P. R. China Institute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036 P. R. China Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, 518036 P. R. China E-mail: [email protected]; [email protected]; [email protected] Search for more papers by this authorZhihui Huang Center of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036 P. R. China Institute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036 P. R. China Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, 518036 P. R. China Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China Search for more papers by this authorJinju Lin Center of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036 P. R. China Institute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036 P. R. China Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, 518036 P. R. China Search for more papers by this authorXiaojun Wang Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, P. R. China Search for more papers by this authorJiqiang Liu Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China Search for more papers by this authorChunyi Zhou China Railway Lanzhou Group Co., Ltd, Lanzhou, 518024 P. R. China Search for more papers by this authorQingqing Zhang Stem Cell & Regenerative Medicine Consortium, School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, 5/F, Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road, Hong Kong, P. R. China Centre for Translational Stem Cell Biology, 17 W Science Park, Hong Kong SAR, P. R. China Search for more papers by this authorPing Gong Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China Search for more papers by this authorLintao Cai Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China Sino-Euro Center of Biomedicine and Health, Shenzhen, 518024 P. R. China Search for more papers by this authorCorresponding Author Pengfei Zhang Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China E-mail: [email protected]; [email protected]; [email protected] Search for more papers by this authorCorresponding Author He Zhang Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044 P. R. China E-mail: [email protected]; [email protected]; [email protected] Search for more papers by this authorCorresponding Author Huashan Zhao Center of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036 P. R. China Institute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036 P. R. China Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, 518036 P. R. China E-mail: [email protected]; [email protected]; [email protected] Search for more papers by this authorAbstract Endometriosis (EM) is a non-cancerous disease that exhibits certain tumor-like properties. While hormonal therapies and surgical excision are standard treatments with proven efficacy in alleviating EM symptoms, they are often accompanied by side effects and a high risk of recurrence after surgery. Therefore, there is an urgent need for non-invasive imaging and therapeutic strategies to address this condition effectively. In this study, second-window near-infrared (NIR-II, 1000–1700 nm) fluorescence imaging is employed, which offers superior spatial resolution, deeper tissue penetration, reduced light scattering, and minimal tissue autofluorescence, to identify EM lesions using aggregation-induced emission luminogen dots (AIE dots). The AIE dots exhibited excellent photothermal properties, achieving a photothermal conversion efficiency of 40%. AIE dots efficiently accumulate at the lesion site through the enhanced permeability and retention (EPR) effect and rapidly heat up to 50 °C under 808 nm laser irradiation, facilitating the effective ablation of EM lesions. Histological analysis, including hematoxylin and eosin (HE) staining and immunofluorescence staining, confirmed notable reduction of the EM lesions, indicating effective inhibition of lesion progression. This strategy highlights the potential of NIR-II fluorescence-guided photothermal therapy as a promising non-invasive approach for both the diagnosis and treatment of EM. Conflict of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. 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