Specific Photothermal Ablation Therapy of Endometriosis by Targeting Delivery of Gold Nanospheres

Xiaomeng Guo, Wei Li, Jialin Zhou, Wanqing Hou, Xue Wen, Hanbo Zhang, Fenfen Kong, Lihua Luo, Qingpo Li, Yongzhong Du, Jian You
Small (Weinheim an der Bergstrasse, Germany) · 2017 · vol. 13(15) · doi:10.1002/smll.201603270 · PMID:28145630 · W2585491907
article OA: closed CC0 ⤵ 17 in-corpus citations
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TNYL-conjugated gold nanospheres specifically target EphB4 receptors in endometriosis lesions, enabling photothermal ablation therapy that inhibits lesion growth and reduces inflammation and hormonal imbalance without toxicity.

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Abstract

Endometriosis is difficult to treat since the side effects of the current therapeutic method and the high recurrence rate; thus, newer and safer therapeutic approaches are urgently needed. This work investigates the enhanced permeability and retention effect of CdTe quantum dots (QDs) and hollow gold nanospheres (HAuNS) in endometriosis to increase the delivery of HAuNS into lesion cells. The surface of HAuNS is successfully conjugated with a TNYL peptide that has specific affinity for the EphB4 receptor, which is a member of the Eph family of receptor tyrosine kinases. It is found that the EphB4 receptor is overexpressed in endometriosis lesions. The data indicate that both QDs and HAuNS can efficiently accumulate in endometriotic lesions through permeable vessels and the TNYL-conjugated HAuNS (TNYL-HAuNS) accumulate more via the interaction with EphB4. The specific photothermal ablation therapy based on TNYL-HAuNS significantly inhibits the growth of the endometriotic volume and induces the atrophy and degeneration of ectopic endometrium with no detectable toxicity to the normal organs. The level of TNF-α and estradiol also significantly decreases in the endometriotic lesions, indicating that the treatment enables a recovery from hormonal imbalance and inflammatory injury. This work can be a valuable reference for future endometriosis therapy.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Ablation Techniques Endometriosis Gold Hyperthermia, Induced Nanospheres Phototherapy Animals Cadmium Compounds Cadmium Compounds Disease Models, Animal Endometriosis Endometriosis Female Gold Mice Nanospheres Nanospheres Peptides Peptides Quantum Dots

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (39)

Cited by (17)

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License: CC0 · commercial use OK