Neutrophil hitchhiking liposomal drugs for starvation therapy in endometriosis

Mengni Zhou, Ying Wang, Caihua Li, Jinfu Li, Jingfu Li, Renbin Dou, Huanhuan Jiang, Yunjiao Zhang, Dawei Chen, Jiqian Zhang, Shasha Zhu
Theranostics · 2025 · vol. 15(10) , pp. 4848–4860 · doi:10.7150/thno.107758 · PMID:40225582 · W4409300653
article OA: gold CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Researchers developed a novel neutrophil-hitchhiking liposomal drug delivery system for non-hormonal treatment of endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study designed a ROS-responsive liposome modified with neutrophil-targeting peptides to exploit neutrophil recruitment to endometriotic lesions and to deliver a “starvation therapy” payload. In a minimally invasive mouse model of endometriosis, the ROS-responsive, neutrophil-hitchhiking liposome (cLipo) bound neutrophils and selectively accumulated in ectopic lesions after intraperitoneal injection; a co-loaded formulation (cLipo-DC) carrying the glycolysis inhibitor 2-deoxy-D-glucose and the autophagy inhibitor chloroquine showed in vitro inhibition of glycolysis and autophagy with cell death in human endometriotic (12Z) and endometrial cancer (Ishikawa) cells. In vivo, cLipo-DC produced a significant anti-endometriosis effect with no detectable side effects, with the main stated caveat being reliance on preclinical modeling and cell lines rather than direct clinical testing. This paper is centrally about endometriosis — it presents neutrophil hitchhiking ROS-responsive liposomal delivery of glycolysis/autophagy inhibitors as non-hormonal starvation therapy for endometriosis.

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Abstract

This study provides a novel neutrophil hitchhiking platform for non-hormonal treatment of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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