Intraperitoneal immune cell status in infertile women with and without endometriosis

Tariverdian N, Nadja Tariverdian, N Tariverdian, F Siedentopf, Friederike Siedentopf, Siedentopf F, M Rücke, Rücke M, S M Blois, Sandra M. Blois, B F Klapp, Klapp BF, Heribert Kentenich, H. Kentenich, Kentenich H, Petra Arck, P C Arck
Journal of Reproductive Immunology · 2009 · vol. 80(1-2) , pp. 80–90 · doi:10.1016/j.jri.2008.12.005 · PMID:19375804 · W2054357641
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This study investigated the types and numbers of immune cells within the abdominal cavity of infertile women, comparing those with and without endometriosis.

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Abstract

Endometriosis is a widespread chronic disease characterized by endometrial tissue located outside the uterine cavity. Clinical signs are chronic pelvic pain and infertility. Emerging evidence indicates that the immune system is profoundly involved in the onset and/or progression of endometriosis. However, mechanistic pathways have not yet been conclusively specified. In this study, women undergoing diagnostic laparoscopy due to infertility were recruited, and classified as early-stage endometriosis (n=30), advanced-stage endometriosis (n=8) or no endometriosis (n=31). The frequency and phenotype of leukocytes were evaluated in peritoneal fluid. While the frequency of lymphocytes was not significantly different, neutrophils were increased in endometriosis. Flow cytometry analysis revealed an increased frequency of CD4(+) and CD8(+) cells in peritoneal fluid of endometriosis patients. In addition, the frequency of CD4(+)CD25(+)CD103(+) cells and lineage(-)HLA-DR(+)CD11c(+)CD123(+) dendritic cells was decreased in peritoneal fluid in endometriosis, whereas CD57(+) NK cells and CD8(+)CD28(-) T suppressor cells remained largely unaltered. We conclude that therapeutic approaches in endometriosis might focus on peritoneal leukocytes as a target or surveillance marker; however, immune alterations in peritoneal fluid are subtle and their analysis will require highly standardized and harmonized protocols.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Antigens, CD Ascitic Fluid Endometriosis Leukocytes Adult Antigens, CD Antigens, CD Ascitic Fluid Ascitic Fluid Cell Differentiation Cell Lineage Cell Proliferation Cell Separation Dendritic Cells Dendritic Cells Dendritic Cells Dendritic Cells Disease Progression Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (50)

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