Inflammatory markers in endometriosis: reduced peritoneal neutrophil response in minimal endometriosis

Christopher Finne Riley, Mette Haase Moen, Vibeke Videm
Acta obstetricia et gynecologica Scandinavica · 2007 · vol. 86(7) , pp. 877–881 · doi:10.1080/00016340701417398 · PMID:17611835 · W2035271221
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In endometriosis patients, lower peritoneal lactoferrin and myeloperoxidase indicated a reduced neutrophil response in minimal disease, while more extensive disease showed stronger neutrophil activation.

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Abstract

BACKGROUND: Inflammation is considered to play a role in the pathogenesis of endometriosis. Inflammatory activation in endometriosis was tested based on the hypothesis that pain and endometriosis stage are related to the degree of local and systemic inflammation. METHODS: Eighteen patients with endometriosis and 14 controls without endometriosis were studied. Cancer antigen 125 and C-reactive protein were analyzed in blood, and in aspirated peritoneal fluid, lactoferrin, myeloperoxidase (neutrophil granulocyte activation marker), sC5b-9 (terminal complement complex), soluble intercellular adhesion molecule 1 (marker for extent of endometriotic tissue), neopterin, and tumor necrosis factor alpha (monocyte/macrophage activation) were evaluated and related to pain, endometriosis stage, and clinical data. RESULTS: None of the measured markers were different between control and endometriosis patients, or in women with or without menstrual pain, dyspareunia, or other types of pelvic pain. Lactoferrin and myeloperoxidase concentrations were significantly lower in patients with endometriosis stage I compared to control patients and endometriosis patients with stage III/IV disease. As expected, cancer antigen 125 concentrations were increased in endometriosis patients of stage III/IV. CONCLUSIONS: Neutrophil granulocytes in endometriosis patients may have a lowered ability to respond to weak activation signals, while in more extensive endometriosis stronger neutrophil activation may be related to a proinflammatory effect of endometriotic tissue.

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Condition tags

endometriosisdyspareunia

MeSH descriptors

Endometriosis Neutrophils Adult Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid CA-125 Antigen CA-125 Antigen Complement Membrane Attack Complex Complement Membrane Attack Complex C-Reactive Protein C-Reactive Protein Endometriosis Endometriosis Endometriosis Female Humans Intercellular Adhesion Molecule-1 Intercellular Adhesion Molecule-1

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