Identification of local angiogenic and inflammatory markers in the menstrual blood of women with endometriosis

da Silva CM, Cláudia Maria da Silva, Andrezza Vilaça Belo, Andrezza V. Belo, Vilaça Belo A, Passos Andrade S, Sílvia Passos Andrade, Peixoto Campos P, Paula Peixoto Campos, Márcia Cristina França Ferreira, Cristina França Ferreira M, Agnaldo Lopes da Silva Filho, Lopes da Silva-Filho A, Agnaldo Lopes da Silva-Filho, Mendonça Carneiro M, Márcia Mendonça Carneiro
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2014 · vol. 68(7) , pp. 899–904 · doi:10.1016/j.biopha.2014.08.005 · PMID:25218120 · W2006241908
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This study identified local angiogenic and inflammatory markers present in the menstrual blood of women diagnosed with endometriosis.

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Abstract

The aim of this study was to evaluate the presence of myeloperoxidase (MPO), N-acetyl-β-D-glucosaminidase (NAG), tumor necrosis factor alpha (TNF-α) and vascular endothelial growth factor (VEGF) in peripheral and menstrual blood in women with (n=10) and without (n=7) endometriosis. NAG and MPO activities were evaluated by enzymatic methods, whereas TNF-α and VEGF by immunoassay. No significant differences were found for these markers, neither in menstrual nor in peripheral blood between groups. Menstrual blood NAG (P=0.039) and MPO (P=0.0117) activities in the endometriosis group were significantly higher than in peripheral blood. NAG and MPO presented positive linear correlation in peripheral (P=0.07; r=0.641) and menstrual blood (P=0.01; r=0.603). These findings point to the existence of an increased local inflammatory activity in women with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers Endometriosis Inflammation Menstrual Cycle Neovascularization, Pathologic Adult Biomarkers Endometriosis Female Humans Inflammation Menstrual Cycle Middle Aged Neoplasm Proteins Neoplasm Proteins Neovascularization, Pathologic Peroxidase Peroxidase Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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