ORIGINAL ARTICLE: Tumor Necrosis Factor (TNF)–TNF Receptor Gene Polymorphisms and Their Serum Levels in Korean Women with Endometriosis

Soo Jin Chae, Hoon Kim, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim, Jung Gu Kim
American journal of reproductive immunology (New York, N.Y. : 1989) · 2008 · vol. 60(5) , pp. 432–439 · doi:10.1111/j.1600-0897.2008.00641.x · PMID:19238748 · W2148682357
article OA: closed CC0 ⤵ 21 in-corpus citations
View on OpenAlex View on PubMed View at publisher

Abstract

PROBLEM: The aim of this study was to investigate the relationship between the polymorphisms of the tumor necrosis factor-alpha (TNT-alpha) and TNF receptor (TNFR) genes and serum levels of TNF-alpha and its soluble receptor (sTNFR) in Korean women with endometriosis. METHOD OF STUDY: The TNF-alpha C(-857)T, C(-863)A and T(-1031)C, and TNFR1 A(36)G. TNFR2 T(676)G, A(1663)G, T(1668)G and C(1690)T polymorphisms, and serum levels of TNF-alpha, sTNFR1, and sTNFR2 were analyzed in women with (n = 105) and without endometriosis (n = 101). RESULTS: Serum sTNFR1 and sTNFR2 levels were significantly higher in women with endometriosis than in those without endometriosis, whereas no difference in serum TNT-alpha level was noted. Single polymorphisms of TNT-alpha and TNFR genes were not significantly different between the two groups. The frequencies of the TNF-alpha T/C/C haplotype allele and the TNFR2 G/G/T haplotype allele were significantly decreased in women with endometriosis compared to women without endometriosis. Women carrying at least one copy of the TNFR2 T/G/T and /or G/G/C haplotype allele had an approximately two times higher risk of endometriosis than women without these haplotype alleles. CONCLUSION: The haplotype alleles of the TNT-alpha and TNFR2 gene polymorphisms are genetic factors associated with endometriosis, and circulating sTNFR rather than TNT-alpha, may be involved in the development of endometriosis in Korean women.

My notes (saved in your browser only)

Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Receptors, Tumor Necrosis Factor Receptors, Tumor Necrosis Factor Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha Adult Alleles Endometriosis Endometriosis Female Gene Frequency Gene Frequency Genotype Haplotypes Haplotypes Humans Korea Korea Polymorphism, Genetic

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (36)

Cited by (21)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:14:11.755070+00:00
unpaywall
last seen: 2026-06-04T02:00:05.705006+00:00
License: CC0 · commercial use OK