Reduced Levels of Serum Pigment Epithelium-Derived Factor in Women With Endometriosis

Liqing Chen, Ruijia Fan, Xiufeng Huang, Hong Xu, Xinmei Zhang
Reproductive sciences (Thousand Oaks, Calif.) · 2011 · vol. 19(1) , pp. 64–69 · doi:10.1177/1933719111413300 · PMID:22051848 · W2012106487
article OA: closed CC0 ⤵ 15 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Serum pigment epithelium-derived factor (PEDF) levels were lower in women with endometriosis, especially those experiencing pain, compared to women without the condition.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study measured serum pigment epithelium-derived factor (PEDF) in 71 women undergoing laparoscopic surgery (43 with endometriosis and 28 without) using enzyme-linked immunosorbent assay, following prior findings of reduced PEDF in peritoneal fluid. Serum PEDF levels were significantly lower in women with endometriosis (16.3 ± 6.6 ng/mL) than in those without (24.5 ± 7.3 ng/mL; P < .001), and within the endometriosis group PEDF was lower in women with pain than those without pain (12.6 ± 7.1 vs 17.5 ± 6.0 ng/mL; P < .05). The authors report no correlation between serum PEDF and disease stage, site, infertility status, or menstrual cycle phase. This paper is centrally about endometriosis — it tests whether decreased PEDF observed in peritoneal fluid also appears as reduced serum PEDF, with an additional association with endometriosis-related pain.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Eye Proteins Nerve Growth Factors Serpins Adult Biomarkers Biomarkers Case-Control Studies Endometriosis Endometriosis Eye Proteins Female Humans Nerve Growth Factors Pigment Epithelium-Derived Factor Serpins

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References (53)

Cited by (16)

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