Endometriosis Biomarkers in Body Fluids

In: Cancer Biomarkers in Body Fluids · 2016 · pp. 399–416 · doi:10.1007/978-3-319-48360-3_14 · W2551247111
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This paper reviews peripheral biomarkers for the non-invasive diagnosis of endometriosis, evaluating circulating cell-free DNA, microRNAs, serum proteins, and autoantibodies.

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This paper chapter reviews biomedical research on biomarkers in body fluids for endometriosis, covering candidate molecules across blood, serum, plasma, urine, and peritoneal fluid, including methylation changes (e.g., HOXA10), circulating cell-free DNA, genome- and serum microRNA profiles, cytokines and immune markers, proteomic and peptidomic signals, and autoantibodies. The chapter synthesizes evidence from multiple experimental and clinical study types, highlighting that many biomarker panels and single markers (e.g., CA-125 in a meta-analysis, or microRNA/protein signatures) have reported diagnostic associations across disease stages. A major limitation, reflected across such biomarker work and noted implicitly by the breadth of included studies, is that performance and applicability can vary by specimen type, assay platform, and study design, making generalization difficult. This paper is centrally about endometriosis — it focuses on biomarkers in body fluids for noninvasive detection and characterization of endometriosis.

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References

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Springer, Cham. https://doi.org/10.1007/978-3-319-48360-3_14 Download citation DOI: https://doi.org/10.1007/978-3-319-48360-3_14 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-319-48359-7 Online ISBN: 978-3-319-48360-3 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)

Keywords

- Chronic Fatigue Syndrome - Peritoneal Fluid - Promoter Hypermethylation - Endometrial Tissue - Endometriotic Lesion These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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