Copeptin is associated with the severity of endometriosis

Abdullah Tuten, Abdullah Tüten, Mine Kucur, Mine Kücür, Metehan Imamoglu, Metehan İmamoğlu, Barış Kaya, Baris Kaya, Abdullah Serdar Acikgoz, Abdullah Serdar Açıkgöz, Nevin Yilmaz, Nevin Yılmaz, Zeynep Ozturk, Zeynep Öztürk, Mahmut Öncül, Mahmut Oncul
Archives of gynecology and obstetrics · 2014 · vol. 290(1) , pp. 75–82 · doi:10.1007/s00404-014-3163-2 · PMID:24488583 · W2075586126
article OA: closed CC0 ⤵ 18 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

Serum copeptin levels are elevated in women with endometriosis and correlate positively with disease severity and endometrioma size.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This case–control study evaluated whether serum copeptin differed between 50 women with surgically proven endometriosis and 36 women without endometriosis, and whether copeptin related to disease severity; participants were grouped into minimal–mild versus moderate–severe (stages 1–2 vs 3–4) and serum copeptin, CA-125, CA-19-9, CA-15-3, and C-reactive protein were measured. Serum copeptin and multiple tumor markers were higher in the endometriosis group, and copeptin (and CA-19-9) were significantly higher in stage 3–4 than stage 1–2, with copeptin positively correlated with disease stage and endometrioma size. A ROC analysis reported CA-125 as having the highest AUC for predicting endometriosis; the paper does not state additional limitations in the provided text beyond its case–control design. This paper is centrally about endometriosis — it tests whether serum copeptin is associated with the presence and severity of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Biomarkers, Tumor C-Reactive Protein Endometriosis Endometriosis Glycopeptides Adult Biomarkers, Tumor CA-125 Antigen CA-125 Antigen CA-19-9 Antigen CA-19-9 Antigen Case-Control Studies C-Reactive Protein C-Reactive Protein Endometriosis Endometriosis Endometrium Endometrium Female Glycopeptides

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License: CC0 · commercial use OK