Two-dimensional gel electrophoresis in peritoneal fluid samples identifies differential protein regulation in patients suffering from peritoneal or ovarian endometriosis

Wölfler MM, Monika M Wölfler, Monika Wölfler, Ivo M Meinhold-Heerlein, Ivo Meinhold‐Heerlein, Linda Söhngen, Söhngen L, Rath W, Werner Rath, Knüchel R, Ruth Knüchel, Joseph Neulen, Neulen J, J. Neulen, Nicolai Maass, Maass N, Nicolaì Maass, Corinna Henkel, Henkel C
Fertility and sterility · 2011 · vol. 95(8) , pp. 2764–2768 · doi:10.1016/j.fertnstert.2011.03.061 · PMID:21497343 · W2017775910
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This study used two-dimensional gel electrophoresis to identify proteins differentially regulated in peritoneal fluid samples from patients with peritoneal or ovarian endometriosis.

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Abstract

Endometriosis is determined by local and systemic proinflammatory dysregulation and therefore differential protein expression in peritoneal fluid (PF). Of highest interest is lesion formation and the establishment and persistence of endometriosis. In this study we analyzed well-characterized PF samples of patients with ovarian or peritoneal endometriosis and compared them to control samples. We found 11 proteins differentially regulated, of which some might play a key role in the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Electrophoresis, Gel, Two-Dimensional Endometriosis Ovarian Diseases Peritoneal Diseases Proteins Proteomics Adolescent Adult Ascitic Fluid Biomarkers Biomarkers Case-Control Studies Endometriosis Endometriosis Female Germany Humans Middle Aged Ovarian Diseases

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (28)

Cited by (17)

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