Evaluation of elevated urinary enolase I levels in patients with endometriosis

Bo Hyon Yun, You Sun Lee, Lee YS, Seung Joo Chon, Chon SJ, Jung YS, Yeon Soo Jung, Su Youn Yim, Yim SY, Hye Yeon Kim, Kim HY, Joo Hyun Park, Park JH, Seok Kyo Seo, SiHyun Cho, Young Sik Choi, Byung Seok Lee, Lee BS
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2013 · vol. 19(1) , pp. 16–21 · doi:10.3109/1354750x.2013.863973 · PMID:24283984 · W2050558848
Diagnostic accuracy OA: green CC0 ⤵ 17 in-corpus citations
🔓 Open OA copy Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Urinary enolase I levels, corrected for creatinine, were significantly elevated in endometriosis patients, suggesting its potential as a biomarker when combined with serum CA-125.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text ⓘ

This case-control study evaluated urinary enolase I as a potential biomarker in 39 women with histologically confirmed endometriosis versus 20 women without endometriosis, using western blot and enzyme-linked immunosorbent assay. The urinary non-neuronal enolase (NNE)-creatinine ratio was significantly higher in endometriosis patients, and combining NNE-Cr with serum CA-125 yielded an area under the ROC curve of 0.821, with reported sensitivity and specificity of 76.9% and 85.0%, respectively. A key limitation is the relatively small sample size and lack of discussion of broader external validation in the provided text. This paper is centrally about endometriosis — it tests and validates elevated urinary enolase I (NNE-Cr) alone and combined with CA-125 for diagnostic performance.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

OBJECTIVE: The aim of this study is to validate and investigate the clinical value of urinary enolase I in patients with endometriosis. METHODS: Urine samples of 39 patients with histologically confirmed endometriosis and 20 patients without endometriosis were collected. Western blot analysis and enzyme-linked immunosorbent assay were used to detect the increase of enolase I in patients' urine. RESULTS: Urinary enolase I expression corrected for creatinine ratio (non neuronal enolase (NNE)-Cr) was significantly greater in patients with endometriosis (p = 0.026). When the diagnostic performance of NNE-Cr was evaluated with serum CA-125 combination, the area under the curve was 0.821 (95% confidence interval 0.713-0.928) with sensitivity and specificity of 76.9% and 85.0%, respectively. CONCLUSION: Elevated urinary enolase I, in conjunction with serum CA-125, may be used as a potential biomarker for endometriosis.
Full text 2,471 characters · extracted from oa-html · 3 sections · click to expand

Methods

Urine samples of 39 patients with histologically confirmed endometriosis and 20 patients without endometriosis were collected. Western blot analysis and enzyme-linked immunosorbent assay were used to detect the increase of enolase I in patients' urine.

Results

Urinary enolase I expression corrected for creatinine ratio (non neuronal enolase (NNE)-Cr) was significantly greater in patients with endometriosis (p = 0.026). When the diagnostic performance of NNE-Cr was evaluated with serum CA-125 combination, the area under the curve was 0.821 (95% confidence interval 0.713-0.928) with sensitivity and specificity of 76.9% and 85.0%, respectively.

Conclusion

Elevated urinary enolase I, in conjunction with serum CA-125, may be used as a potential biomarker for endometriosis. - Appears in Collections: - 1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers - Yonsei Authors - Kim, Hye Yeon(김혜연) Park, Joo Hyun(박주현) Seo, Seok Kyo(서석교) https://orcid.org/0000-0003-3404-0484 Yun, Bo Hyon(윤보현) https://orcid.org/0000-0001-5703-797X Lee, Byung Seok(이병석) https://orcid.org/0000-0001-6001-2079 Yim, Su Youn(임수연) Chon, Seung Joo(전승주) Cho, Si Hyun(조시현) https://orcid.org/0000-0003-2718-6645 Choi, Young Sik(최영식) https://orcid.org/0000-0002-1157-4822 Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

MeSH descriptors

Biomarkers, Tumor DNA-Binding Proteins Endometriosis Phosphopyruvate Hydratase Tumor Suppressor Proteins Adult Adult Biomarkers Biomarkers Biomarkers Biomarkers, Tumor Biomarkers, Tumor CA-125 Antigen CA-125 Antigen CA-125 Antigen Case-Control Studies Case-Control Studies Creatinine Creatinine Creatinine

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (41)

Cited by (17)

Source provenance

europepmc
last seen: 2026-10-14T06:08:39.101224+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:12:56.342978+00:00
License: CC0 · commercial use OK