{"paper_id":"d483fe8f-fc09-4522-bf6c-f68cf08140f0","body_text":"YUHASpace Repository\n3\n1073\nCited 0 times in\nCited 16 times in\nEvaluation of elevated urinary enolase I levels in patients with endometriosis.\n- Authors\n- Bo Hyon Yun ; You Sun Lee ; Seung Joo Chon ; Yeon Soo Jung ; Su Youn Yim ; Hye Yeon Kim ; Joo Hyun Park ; Seok Kyo Seo ; SiHyun Cho ; Young Sik Choi ; Byung Seok Lee\n- Citation\n- BIOMARKERS, Vol.19(1) : 16-21, 2014\n- Journal Title\n- BIOMARKERS\n- ISSN\n- 1354-750X\n- Issue Date\n- 2014\n- MeSH\n- Adult ; Biomarkers/urine ; Biomarkers, Tumor/urine* ; CA-125 Antigen/blood ; Case-Control Studies ; Creatinine/urine ; DNA-Binding Proteins/urine* ; Endometriosis/diagnosis ; Endometriosis/enzymology ; Endometriosis/urine* ; Female ; Humans ; Phosphopyruvate Hydratase/urine* ; ROC Curve ; Tumor Suppressor Proteins/urine*\n- Keywords\n- Biomarker ; endometriosis ; enolase I ; urine\n- Abstract\n- OBJECTIVE: The aim of this study is to validate and investigate the clinical value of urinary enolase I in patients with endometriosis.\nMETHODS: Urine samples of 39 patients with histologically confirmed endometriosis and 20 patients without endometriosis were collected. Western blot analysis and enzyme-linked immunosorbent assay were used to detect the increase of enolase I in patients' urine.\nRESULTS: Urinary enolase I expression corrected for creatinine ratio (non neuronal enolase (NNE)-Cr) was significantly greater in patients with endometriosis (p = 0.026). When the diagnostic performance of NNE-Cr was evaluated with serum CA-125 combination, the area under the curve was 0.821 (95% confidence interval 0.713-0.928) with sensitivity and specificity of 76.9% and 85.0%, respectively.\nCONCLUSION: Elevated urinary enolase I, in conjunction with serum CA-125, may be used as a potential biomarker for endometriosis.\n- Appears in Collections:\n- 1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers\n1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers\n- Yonsei Authors\n-\nKim, Hye Yeon(김혜연)\nPark, Joo Hyun(박주현)\nSeo, Seok Kyo(서석교) https://orcid.org/0000-0003-3404-0484\nYun, Bo Hyon(윤보현) https://orcid.org/0000-0001-5703-797X\nLee, Byung Seok(이병석) https://orcid.org/0000-0001-6001-2079\nYim, Su Youn(임수연)\nChon, Seung Joo(전승주)\nCho, Si Hyun(조시현) https://orcid.org/0000-0003-2718-6645\nChoi, Young Sik(최영식) https://orcid.org/0000-0002-1157-4822\nItems in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.","source_license":"CC0","license_restricted":false}