The diagnostic value of the combination of hemoglobin, CA199, CA125, and HE4 in endometriosis

Chen T, Ting Chen, Jia‐Ling Wei, Wei JL, Jia-Ling Wei, Leng T, Ting Leng, Fei Gao, Shun-Yu Hou, Shunyu Hou, Hou SY
Journal of clinical laboratory analysis · 2021 · vol. 35(9) , pp. e23947 · doi:10.1002/jcla.23947 · PMID:34405450 · PMC8418510 · W3194969437
article OA: gold CC0 ⤵ 20 in-corpus citations
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This study found that a diagnostic model combining hemoglobin, CA199, CA125, and HE4 achieved high sensitivity and specificity for diagnosing endometriosis compared to individual markers.

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Abstract

BACKGROUND: We aimed to analyze the differences in the peripheral blood cells and tumor biomarkers between the patients with endometriosis and healthy people, and establish a more efficient combined diagnostic model. METHODS: We retrospectively analyzed the differences in the peripheral blood cells and tumor biomarkers between the patients with endometriosis and healthy people. Binary logistic regression analysis was used to establish a combined diagnostic model. We plotted the receiver operator characteristic (ROC) curve to analyze the diagnostic efficiency of different diagnostic indexes. RESULTS: Compared with patients in the control group, patients in the endometriosis group had significantly lower eosinophil% (p = 0.045), neutrophil (p = 0.001), lymphocyte (p < 0.001), red blood cells (RBCs) (p < 0.001), and hemoglobin (HGB) (p < 0.001), and had significantly higher monocyte% (p = 0.008), monocyte-to-lymphocyte ratio (MLR) (p = 0.001), platelet-to-lymphocyte ratio (PLR) (p < 0.001), carbohydrate antigen (CA)-199 (p < 0.001), CA125 (p < 0.001), human epididymis protein (HE)-4 (p < 0.001), and the risk of ovarian malignancy algorithm (ROMA) (p < 0.001). The combined diagnostic model of HGB, CA199, CA125, and HE4 was established by binary logistic regression analysis. The ROC curve showed that the combined diagnostic model reached a sensitivity of 85.4%, a specificity of 78.83%, and an area under the curve of 0.900, which was significantly higher than that of the individual index in endometriosis diagnosis. CONCLUSION: The combined diagnostic model of HGB, CA199, CA125, and HE4 may provide a new approach for the early non-invasive diagnosis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Algorithms Antigens, Tumor-Associated, Carbohydrate Biomarkers CA-125 Antigen Endometriosis Hemoglobins Membrane Proteins WAP Four-Disulfide Core Domain Protein 2 Adult Antigens, Tumor-Associated, Carbohydrate Biomarkers Blood Platelets Blood Platelets CA-125 Antigen Case-Control Studies Endometriosis Endometriosis Female Hemoglobins Humans

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References (24)

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