Proteomics in endometriosis

Piotr Marianowski, Iwona Szymusik, Hibner M, Michał Hibner, Ewa Barcz, M. Hibner, Mirosław Wielgoś
Ginekologia polska · 2013 · vol. 84(10) , pp. 877–81 · doi:10.17772/gp/1655 · PMID:24273911 · W2006814496
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Proteomics enables visualization and comparison of protein alterations in endometriosis tissues to identify potential biomarkers and therapeutic targets for the enigmatic disease.

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The provided text appears to be a collection of unrelated snippets regarding general health topics, such as folic acid, buckwheat honey, vitamin B12, and pediatric hemangiomas, rather than a cohesive research paper on proteomics. The title "Proteomics in endometriosis" does not align with the content, which lacks any scientific methodology, data analysis, or discussion of biological markers associated with gynecological conditions. Consequently, it is impossible to summarize specific findings, population methods, or limitations from this disjointed set of articles. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Despite significant scientific progress, etiology of endometriosis remains enigmatic. New advances in molecular biology have allowed the use of proteomics in demystifying this puzzling disease. Proteomics is a technology that permits the visualization of thousands of proteins inside a cell, tissue, or organism, and simultaneous observation of any alterations in protein expression and post-translational modification that may have important, clinical implications. Owing to its capacity to reveal the structural and functional properties of proteins, proteomics might illuminate the biology of the disease much better than genomics can. This state-of-the-art technology allows us to globally compare the expression and regulation profiles of proteins found in endometriosis with normal eutopic tissues (endometrium and peritoneum), as well as to compare those found in the different forms of endometriosis (i.e., peritoneal endometriosis, endometrioma, and adenomyoma). Proteomic analysis has been employed in endometriosis research in hope of discovering endometriosis-specific proteins, pathways, and potential biomarkers for precise, early detection. In recent years, several published studies have compared serum and peritoneal fluid protein content in women with and without endometriosis, as well as protein composition in endometrial implants, eutopic endometrium, endometriomas, menstrual blood and urine. It appears that use of proteomics could revolutionize our understanding of etiopathogenesis of the disease. Some of the identified proteins could indeed be responsible for the onset and progression of endometriotic implants. Because early stages of endometriosis may be difficult to diagnose, it would be of the utmost importance to identify specific biological markers of the disease. Additionally specific implant proteins could become targets for molecular treatment of endometriosis. It is very challenging, however to draw clear conclusions from the analysis of the obtained samples. First of all, the samples are usually pathologically confirmed to be endometriotic, but from a molecular stand point, the particular portion of the sample that is analyzed may matter greatly; none of the methods allow us to gain information about the molecular and pathological pattern of the same sample. Secondly it is very difficult to define an 'unaffected peritoneum' as a control for the endometriotic lesions. Thirdly the variety of options in each individual makes it difficult to see the molecular picture of the diseased area (such as the ovary or peritoneum) clearly ideally the samples would be of greater value if obtained at an early age, that is, before puberty in each individual and then again when endometriosis occurs later in reproductive age. Such a project cannot be performed prospectively although it may be considered as retrospective analysis of obtained material in some patients after successful chemotherapy due to oncological conditions.
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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Proteome Proteomics Adult Biomarkers Biomarkers Endometriosis Female Glycoproteins Glycoproteins Humans Proteome Proteomics Retrospective Studies

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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