Role of cytokines in the endometrial-peritoneal cross-talk and development of endometriosis

Cleophas Kyama, Kyama CM, Cleophas M Kyama, Mihalyi A, Attila Mihalyi, Peter Simsa, Simsa P, Henrik Falconer, Vilmos Fulop, Fulop V, Mwenda JM, Jason M. Mwenda, Karen Peeraer, Carla Tomassetti, Christel Meuleman, Meuleman C, D'Hooghe TM, Thomas M D'Hooghe
Frontiers in bioscience (Elite edition) · 2009 · vol. E1(2) , pp. 444–454 · doi:10.2741/e40 · PMID:19482658 · W33495223
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This review examines how endometrial-peritoneal interactions, orchestrated by cytokines and adhesion molecules, contribute to endometriosis development and pathogenesis, using baboon models to study early lesion formation.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This review examines the role of cytokines in endometrial–peritoneal cross-talk and how these signaling interactions may contribute to the development of endometriosis. It describes how pro-inflammatory and chemoattractant cytokines coordinate interactions between menstrual endometrium and the peritoneal microenvironment, which may promote local inflammatory responses, including recruitment of activated macrophages and leukocytes, and thereby support lesion development. The authors highlight an in vivo primate model in which intrapelvic injection of menstrual endometrium in baboons enables study of early endometrial–peritoneal interactions within an in vivo culture microenvironment. As a review, it synthesizes existing evidence without presenting new experimental limitations beyond its narrative scope. This paper is centrally about endometriosis — it specifically discusses cytokines coordinating endometrial–peritoneal interactions involved in endometriosis development.

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Abstract

A clear picture of the dynamic relationship between the endometrium and peritoneum is emerging as both tissues may participate in the spontaneous development of endometriosis. Various adhesion molecules, pro-inflammatory cytokines and chemoattractants cytokines have emerged as central coordinators of endometrial-peritoneal interactions. The peritoneal microenvironment which consists of the peritoneal fluid, normal peritoneum and peritoneal endometriotic lesions may play an active role in the pathogenesis of endometriosis, by harbouring most inflammatory responses that are triggered by the presence of endometrial cells, leading to recruitment of activated macrophages and leukocytes locally. Menstrual endometrium has the ability to bond and invade the peritoneal tissue. In baboons intrapelvic injection of menstrual endometrium permits the study of early endometrial-peritoneal interaction in an in vivo culture microenvironment and can lead to important insight in the early development of endometriotic lesions. In this review, we discuss the roles of the endometrial-peritoneal interactions, not only in disease development but also in the broader process of aetiopathogenesis.
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Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience. 1 Leuven University Fertility Centre, Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Herestraat 49, B3000 Leuven, Belgium 2 Department of Obstetrics and Gynaecology, Karolinska Hospital, Stockholm, Sweden 3 Division of Reproductive Biology, Institute of Primate Research, P.O Box 24481, Karen 00502, Nairobi, Kenya 4 Department of Obstetrics and Gynaecology, National Health Center, Budapest, Hungary Abstract A clear picture of the dynamic relationship between the endometrium and peritoneum is emerging as both tissues may participate in the spontaneous development of endometriosis. Various adhesion molecules, pro-inflammatory cytokines and chemoattractants cytokines have emerged as central coordinators of endometrial-peritoneal interactions. The peritoneal microenvironment which consists of the peritoneal fluid, normal peritoneum and peritoneal endometriotic lesions may play an active role in the pathogenesis of endometriosis, by harbouring most inflammatory responses that are triggered by the presence of endometrial cells, leading to recruitment of activated macrophages and leukocytes locally. Menstrual endometrium has the ability to bond and invade the peritoneal tissue. In baboons intrapelvic injection of menstrual endometrium permits the study of early endometrial-peritoneal interaction in an in vivo culture microenvironment and can lead to important insight in the early development of endometriotic lesions. In this review, we discuss the roles of the endometrial-peritoneal interactions, not only in disease development but also in the broader process of aetiopathogenesis.

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Condition tags

endometriosis

MeSH descriptors

Cytokines Endometriosis Endometrium Peritoneum Receptor Cross-Talk Signal Transduction Cytokines Endometriosis Endometrium Endometrium Female Humans Hyaluronan Receptors Hyaluronan Receptors Hyaluronan Receptors Integrins Integrins Integrins Matrix Metalloproteinases Matrix Metalloproteinases

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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