Beyond the norm: a systematic review of appendiceal intussusception in endometriosis cases

Mohammad Al-Bdour, Abdel Qader Abu-Salih, Zaid Shakhatreh, Abdulla Zghoul, Mohammad Bani-younes, Ramez M. Odat, Dang Nguyen, Abdulqadir J. Nashwan
In: International Journal of Surgery Open · 2024 · vol. 62(3) , pp. 258–271 · doi:10.1097/io9.0000000000000055 · W4409448767
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This systematic review identified 38 cases of appendiceal intussusception due to endometriosis, finding that symptoms often mimic other conditions and diagnosis is frequently postoperative, highlighting the need for consideration in relevant patient presentations.

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Abstract

Background: Appendiceal intussusception (AI), an uncommon entity with significant clinical importance, various intrinsic pathologies could act as a lead point, with endometriosis being an uncommon etiological factor posing diagnostic challenges for clinicians. Objectives: This systematic review aims to provide valuable insights into the clinical aspects and management of AI caused by endometriosis to better understand this rare condition. Materials and Methods: A systematic search of the literature was conducted in EBSCO, PubMed, ScienceDirect, Scopus, and SpringerLink databases to identify case reports describing AI associated with endometriosis. Data were extracted and organized into categories. The extracted data was entered into standardized Google spreadsheets. The risk of bias was assessed using the JBI Critical Appraisal Checklist. Main Results: The review identified a total of 38 cases with a mean age of 41.58-years-old between 1949 and 2022. Patient’s clinical findings were categorized into being asymptomatic (15.79%), presenting with lower abdominal pain/gastrointestinal complaints (60.53%), or gynecological symptoms (23.68%), often mimicking other abdominal and gynecological disorders, leading to a variety of differential diagnoses with appendicitis being the most common. Most cases were diagnosed postoperatively (44.74%), with colonoscopy and computed tomography playing pivotal roles in preoperative diagnosis. Type V intussusception was most prevalent, and surgical interventions varied, ranging from appendectomy to right hemicolectomy. Postoperative outcomes were generally favorable, with most patients experiencing symptom resolution. Conclusions: Clinicians should consider AI caused by endometriosis as a differential diagnosis in female patients with recurrent cyclic abdominal pain and a cecal mass.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (65)

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