Endometriosis-induced changes in regulatory T cells — insights towards developing permanent contraception

Asgerally T Fazleabas, Fazleabas AT, Andrea Braundmeier, Braundmeier A, Kirstin Parkin, Parkin K
Contraception · 2015 · vol. 92(2) , pp. 116–119 · doi:10.1016/j.contraception.2015.06.006 · PMID:26086573 · PMC4506884 · W2126266367
review OA: closed CC0 ⤵ 15 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This paper investigates how endometriosis alters regulatory T cells and explores these changes as a potential avenue for developing permanent contraception.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BackgroundEndometriosis is a gynecological disorder that is associated with alterations in the immune system that contributes to its pathology as well as its associated infertility.Main findingsThis brief report summarizes our findings related to the changes in T regulatory cells (Tregs) that may affect the uterine environment and impact the fertility of women and nonhuman primates with endometriosis.Principal conclusionTargeted therapies that could reduce Tregs within the reproductive tract may have a potential as long-lasting or permanent contraception.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Immunomodulation Models, Immunological Sterilization, Reproductive T-Lymphocytes, Regulatory Animals Endometriosis Endometriosis Endometrium Endometrium Female Humans Infertility, Female Infertility, Female Papio anubis Sterilization, Reproductive T-Lymphocytes, Regulatory

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (51)

Cited by (15)

Source provenance

europepmc
last seen: 2026-08-15T06:15:18.721777+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:17:52.213533+00:00
License: CC0 · commercial use OK